HitPredict

Interactor 1: CASP2 (P42575)
Caspase-2 (CASP-2) (EC 3.4.22.55) (Neural precursor cell expressed developmentally down-regulated protein 2) (NEDD-2) (Protease ICH-1) [Cleaved into: Caspase-2 subunit p18; Caspase-2 subunit p13; Caspase-2 subunit p12]
Gene: CASP2

Interactor 2: CASP2 (P42575)
Caspase-2 (CASP-2) (EC 3.4.22.55) (Neural precursor cell expressed developmentally down-regulated protein 2) (NEDD-2) (Protease ICH-1) [Cleaved into: Caspase-2 subunit p18; Caspase-2 subunit p13; Caspase-2 subunit p12]
Gene: CASP2

Species: Homo sapiens

Source: mint

Category: Small-scale

Confidence: High

Method score Annotation score Interaction score
0.94 1.00 0.973

The method score is based on:

Property Details
Experiments 25416956, 26871637, 29875129, 32296183, 11832478, 19337385, 11156409, 31515488, unassigned1304, 22531785
Identification Methods two hybrid, protein complementation assay, enzymatic study, two hybrid array, anti tag coimmunoprecipitation, two hybrid prey pooling approach, validated two hybrid, bimolecular fluorescence complementation
Interaction Type direct interaction, physical association

The annotation score is based on:

Property Details
Interacting Pfam domains CARD~CARD, Peptidase_C14~Peptidase_C14
Common GO terms GO:0001554 - luteolysis
GO:0003407 - neural retina development
GO:0004197 - cysteine-type endopeptidase activity
GO:0005634 - nucleus
GO:0005730 - nucleolus
and 21 others

more...
Homologous interactions 20

Homologous interactions (Top 20)

Color coding for hit scores

1 452
Hs

1 452
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Last updated: 15 Jul 2024