HitPredict

Interactor 1: NKX25 (P42582)
Homeobox protein Nkx-2.5 (Cardiac-specific homeobox) (Homeobox protein CSX) (Homeobox protein NK-2 homolog E)
Gene: Nkx2-5

Interactor 2: TBX1 (P70323)
T-box transcription factor TBX1 (T-box protein 1) (Testis-specific T-box protein)
Gene: TBX1

Species: Mus musculus

Source: biogrid

Category: Small-scale

Confidence: High

Method score Annotation score Interaction score
0.38 1.00 0.618

The method score is based on:

Property Details
Experiments 16556915
Identification Methods affinity chromatography technology
Interaction Type physical association

The annotation score is based on:

Property Details
Interacting Pfam domains Homeodomain~T-box
Common GO terms GO:0000122 - negative regulation of transcription by RNA polymerase II
GO:0000978 - RNA polymerase II cis-regulatory region sequence-specific DNA binding
GO:0000981 - DNA-binding transcription factor activity, RNA polymerase II-specific
GO:0001228 - DNA-binding transcription activator activity, RNA polymerase II-specific
GO:0003007 - heart morphogenesis
and 15 others

more...
Homologous interactions 14

Homologous interactions

Color coding for hit scores

1 318
Mm

1 479
+ Mm
+ Hs
+ Mm
+ Mm
+ Hs
+ Mm
+ Mm
+ Hs
+ Dm
+ Dm
+ Dm
+ Dm
+ Dm
+ Dm

Service provided by Combinatics, Japan

Last updated: 15 Jul 2024