HitPredict

Interactor 1: TEC (P42680)
Tyrosine-protein kinase Tec (EC 2.7.10.2)
Gene: TEC

Interactor 2: GRB2 (P62993)
Growth factor receptor-bound protein 2 (Adapter protein GRB2) (Protein Ash) (SH2/SH3 adapter GRB2)
Gene: GRB2

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.47	1.00	0.691

Property	Details
Experiments	21706016
Identification Methods	affinity chromatography technology, anti tag coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	PH~SH3_1, PK_Tyr_Ser-Thr~SH2, PK_Tyr_Ser-Thr~SH3_1, SH2~SH2, SH2~SH3_1, SH3_1~SH3_1
Common GO terms	GO:0005829 - cytosol GO:0005886 - plasma membrane GO:0050853 - B cell receptor signaling pathway
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 631 Hs			1 217
+	Hs
		924520 ITK_HUMAN (1-625): 0: 691: 57.58		GRB2_HUMAN (1-217): 6.71e-76: 229: 100.00
+	Mm
		729751 BTK_MOUSE (5-627): 0: 630: 53.57		GRB2_MOUSE (1-217): 2.48e-76: 230: 99.54
+	Hs
		924503 BTK_HUMAN (5-627): 0: 629: 52.50		GRB2_HUMAN (1-217): 6.71e-76: 229: 100.00
+	Hs
		548654 TEC_HUMAN (1-631): 0: 738: 100.00		VAV_HUMAN (2-60): 8.95e-15: 74.6: 42.37
+	Hs
		433631 TEC_HUMAN (1-631): 0: 738: 100.00		LYN_HUMAN (129-215): 1.44e-11: 65: 22.47
+	Hs
		788974 TEC_HUMAN (1-631): 0: 738: 100.00		FRK_HUMAN (150-212): 6.98e-11: 62.7: 27.78
+	Hs
		412155 ITK_HUMAN (1-625): 0: 691: 57.58		FYN_HUMAN (161-215): 4.44e-14: 72.3: 31.58
+	Hs
		522941 ITK_HUMAN (1-625): 0: 691: 57.58		SRC_HUMAN (161-215): 3.76e-11: 63.8: 31.58
+	Hs
		411650 BMX_HUMAN (1-627): 0: 605: 45.05		LCK_HUMAN (3-202): 3.69e-37: 137: 28.91
+	Hs
		337440 BTK_HUMAN (5-627): 0: 629: 52.50		ABL1_HUMAN (4-139): 4.39e-22: 95.5: 35.46
+	Hs
		548690 BTK_HUMAN (5-627): 0: 629: 52.50		VAV_HUMAN (2-60): 8.95e-15: 74.6: 42.37
+	Hs
		412147 BTK_HUMAN (5-627): 0: 629: 52.50		FYN_HUMAN (161-215): 4.44e-14: 72.3: 31.58
+	Hs
		442813 BTK_HUMAN (5-627): 0: 629: 52.50		HCK_HUMAN (120-215): 1.21e-12: 68.1: 19.39
+	Hs
		433717 BTK_HUMAN (5-627): 0: 629: 52.50		LYN_HUMAN (129-215): 1.44e-11: 65: 22.47
+	Hs
		522868 BMX_HUMAN (1-627): 0: 605: 45.05		SRC_HUMAN (161-215): 3.76e-11: 63.8: 31.58
+	Mm
		337637 ABL1_MOUSE (143-624): 9.94e-170: 515: 37.50		NCK1_MOUSE (5-145): 8.99e-23: 96.3: 33.14
+	Mm
		337615 ABL1_MOUSE (143-624): 9.94e-170: 515: 37.50		ABL1_MOUSE (4-139): 4.07e-22: 95.9: 35.46
+	Hs
		337293 ABL1_HUMAN (143-624): 2.71e-169: 514: 37.30		ABL1_HUMAN (4-139): 4.39e-22: 95.5: 35.46
+	Hs
		337307 ABL1_HUMAN (143-624): 2.71e-169: 514: 37.30		FYN_HUMAN (161-215): 4.44e-14: 72.3: 31.58
+	Hs
		275157 ABL1_HUMAN (143-624): 2.71e-169: 514: 37.30		GRAP2_HUMAN (3-55): 1.58e-10: 61.3: 39.62