Interactor 1: FRK (P42685)
Tyrosine-protein kinase FRK (EC 2.7.10.2) (FYN-related kinase) (Nuclear tyrosine protein kinase RAK) (Protein-tyrosine kinase 5)
Gene: FRK
Interactor 2: PTEN (P60484)
Phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN (EC 3.1.3.16) (EC 3.1.3.48) (EC 3.1.3.67) (Inositol polyphosphate 3-phosphatase) (EC 3.1.3.-) (Mutated in multiple advanced cancers 1) (Phosphatase and tensin homolog)
Gene: PTEN
Species: Homo sapiens
Source: intact
Category: Small-scale
Confidence: High
| Method score | Annotation score | Interaction score |
|---|---|---|
| 0.59 | 1.00 | 0.770 |
The method score is based on:
| Property | Details |
|---|---|
| Experiments | 19345329 |
| Identification Methods | affinity chromatography technology, pull down, anti bait coimmunoprecipitation, anti tag coimmunoprecipitation, protein kinase assay |
| Interaction Type | physical association, phosphorylation reaction |
The annotation score is based on:
| Property | Details |
|---|---|
| Interacting Pfam domains | PK_Tyr_Ser-Thr~Y_phosphatase, SH2~Y_phosphatase |
| Common GO terms | GO:0005576 - extracellular region GO:0005634 - nucleus GO:0005654 - nucleoplasm GO:0005829 - cytosol |
| Homologous interactions | 8 |
Homologous interactions
Color coding for hit scores 
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Service provided by Combinatics, Japan
Last updated: 15 Jul 2024
