HitPredict

Interactor 1: FRK (P42685)
Tyrosine-protein kinase FRK (EC 2.7.10.2) (FYN-related kinase) (Nuclear tyrosine protein kinase RAK) (Protein-tyrosine kinase 5)
Gene: FRK

Interactor 2: TBCK (Q8TEA7)
TBC domain-containing protein kinase-like protein (FERRY endosomal RAB5 effector complex subunit 1) (Fy-1)
Gene: TBCK

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.47	1.00	0.691

Property	Details
Experiments	32707033
Identification Methods	affinity chromatography technology, pull down
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	PK_Tyr_Ser-Thr~Pkinase
Common GO terms	GO:0005524 - ATP binding GO:0005634 - nucleus
Homologous interactions	16

Homologous interactions

Color coding for hit scores

	1 505 Hs			1 893
+	Hs
		523078 SRC_HUMAN (13-503): 1.23e-178: 513: 47.89		TBCK_HUMAN (1-893): 0: 721: 100.00
+	Hs
		433910 LYN_HUMAN (21-495): 3.53e-166: 481: 49.27		TBCK_HUMAN (1-893): 0: 721: 100.00
+	Hs
		411778 LCK_HUMAN (33-495): 2.21e-173: 499: 48.50		MARK2_HUMAN (2-470): 3.46e-114: 369: 18.58
+	Hs
		789116 FRK_HUMAN (1-505): 0: 579: 100.00		KS6A1_HUMAN (5-293): 1.72e-83: 285: 18.40
+	Hs
		433850 LYN_HUMAN (21-495): 3.53e-166: 481: 49.27		MARK2_HUMAN (2-470): 3.46e-114: 369: 18.58
+	At
		84904 Y5169_ARATH (7-495): 8.76e-157: 469: 18.24		CIPKP_ARATH (2-502): 1.92e-119: 373: 14.40
+	Hs
		522867 SRC_HUMAN (13-503): 1.23e-178: 513: 47.89		KS6A3_HUMAN (2-286): 3.69e-83: 284: 18.58
+	Hs
		412205 FYN_HUMAN (30-503): 1.55e-177: 511: 50.63		KS6A1_HUMAN (5-293): 1.72e-83: 285: 18.40
+	Hs
		412095 FYN_HUMAN (30-503): 1.55e-177: 511: 50.63		KS6A3_HUMAN (2-286): 3.69e-83: 284: 18.58
+	Hs
		412203 FYN_HUMAN (30-503): 1.55e-177: 511: 50.63		KS6A2_HUMAN (2-273): 9.1e-82: 280: 18.02
+	Hs
		433360 YES_HUMAN (43-503): 6.27e-174: 502: 49.25		KS6A2_HUMAN (2-273): 9.1e-82: 280: 18.02
+	Hs
		411606 LCK_HUMAN (33-495): 2.21e-173: 499: 48.50		MARK3_HUMAN (27-410): 8.27e-80: 275: 21.13
+	Hs
		433589 LYN_HUMAN (21-495): 3.53e-166: 481: 49.27		MARK3_HUMAN (27-410): 8.27e-80: 275: 21.13
+	Hs
		320504 FRK_HUMAN (1-505): 0: 579: 100.00		OXSR1_HUMAN (37-275): 3.73e-16: 84.7: 28.24
+	Hs
		412167 FYN_HUMAN (30-503): 1.55e-177: 511: 50.63		AAPK1_HUMAN (99-294): 1.55e-15: 82.8: 30.30
+	Hs
		433949 LYN_HUMAN (21-495): 3.53e-166: 481: 49.27		MARK4_HUMAN (31-295): 9e-16: 84: 26.52