HitPredict

Interactor 1: WASP (P42768)
Actin nucleation-promoting factor WAS (Wiskott-Aldrich syndrome protein) (WASp)
Gene: WAS

Interactor 2: PTN12 (Q05209)
Tyrosine-protein phosphatase non-receptor type 12 (EC 3.1.3.48) (PTP-PEST) (Protein-tyrosine phosphatase G1) (PTPG1)
Gene: PTPN12

Species: Homo sapiens

Source: mint

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.58	0.60	0.595

Property	Details
Experiments	19167335, 14707117
Identification Methods	phosphatase assay, anti bait coimmunoprecipitation
Interaction Type	dephosphorylation reaction, physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005634 - nucleus GO:0005829 - cytosol GO:0017124 - SH3 domain binding
Homologous interactions	10

Homologous interactions

Color coding for hit scores

	1 502 Hs			1 780
+	Mm
		728825 WASP_MOUSE (17-487): 1.16e-101: 316: 86.04		PTN12_MOUSE (1-780): 0: 560: 83.10
+	Hs
		441188 WASP_HUMAN (1-487): 8.09e-99: 308: 100.00		PTPRC_HUMAN (13-678): 1.57e-143: 456: 19.30
+	Hs
		126912 WASL_HUMAN (15-311): 1.14e-115: 352: 47.67		PTN2_HUMAN (24-401): 2.72e-123: 377: 23.85
+	Hs
		790695 WASP_HUMAN (1-487): 8.09e-99: 308: 100.00		PTN22_HUMAN (1-779): 6.27e-132: 413: 32.01
+	Hs
		616908 WASP_HUMAN (1-487): 8.09e-99: 308: 100.00		PTPRB_HUMAN (7-314): 1.22e-123: 410: 29.62
+	Hs
		617086 WASP_HUMAN (1-487): 8.09e-99: 308: 100.00		PTPRG_HUMAN (8-299): 1.84e-52: 200: 24.50
+	Hs
		840677 DYN2_HUMAN (244-438): 9.39e-25: 110: 17.54		PTN11_HUMAN (7-351): 1.65e-124: 387: 31.48
+	Hs
		790677 WASP_HUMAN (1-487): 8.09e-99: 308: 100.00		PTPRO_HUMAN (58-303): 3.31e-46: 180: 38.71
+	Hs
		790667 WASP_HUMAN (1-487): 8.09e-99: 308: 100.00		PTPRJ_HUMAN (49-297): 6.23e-46: 179: 39.13
+	Hs
		490001 CBP_HUMAN (107-498): 6.15e-40: 156: 13.65		PTPRF_HUMAN (8-299): 2.83e-90: 313: 31.99