HitPredict

Interactor 1: WASP (P42768)
Actin nucleation-promoting factor WAS (Wiskott-Aldrich syndrome protein) (WASp)
Gene: WAS

Interactor 2: ITSN1 (Q15811)
Intersectin-1 (SH3 domain-containing protein 1A) (SH3P17)
Gene: ITSN1

Species: Homo sapiens

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.56	0.60	0.584

Property	Details
Experiments	18539136, 15824104
Identification Methods	affinity chromatography technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005829 - cytosol GO:0005886 - plasma membrane GO:0016197 - endosomal transport
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 502 Hs			1 1721
+	Hs
		126936 WASL_HUMAN (15-311): 1.14e-115: 352: 47.67		ITSN1_HUMAN (1-1721): 0: 897: 100.00
+	Rn
		94091 F1LSG0_RAT (12-310): 6.88e-120: 362: 47.68		ITSN1_RAT (1-1721): 0: 853: 92.27
+	Hs
		126965 WASL_HUMAN (15-311): 1.14e-115: 352: 47.67		ITSN2_HUMAN (1-1720): 0: 723: 54.73
+	Hs
		790688 WASP_HUMAN (1-487): 8.09e-99: 308: 100.00		ITSN2_HUMAN (1-1720): 0: 723: 54.73
+	Hs
		840702 DYN2_HUMAN (244-438): 9.39e-25: 110: 17.54		ITSN1_HUMAN (1-1721): 0: 897: 100.00
+	Hs
		983379 DYN1_HUMAN (268-428): 5.28e-19: 92.7: 18.01		ITSN1_HUMAN (1-1721): 0: 897: 100.00
+	Mm
		760488 DYN2_MOUSE (244-424): 2.26e-25: 112: 21.47		ITSN1_MOUSE (1-1721): 0: 864: 94.54
+	Mm
		760469 DYN1_MOUSE (268-431): 5.57e-18: 89.2: 24.24		ITSN1_MOUSE (1-1721): 0: 864: 94.54
+	Rn
		599413 DYN1_RAT (268-428): 8.08e-19: 91.9: 18.01		ITSN1_RAT (1-1721): 0: 853: 92.27
+	Hs
		840840 DYN2_HUMAN (244-438): 9.39e-25: 110: 17.54		ITSN2_HUMAN (1-1720): 0: 723: 54.73
+	Hs
		126909 WASL_HUMAN (15-311): 1.14e-115: 352: 47.67		NCK1_HUMAN (895-1055): 6.44e-09: 62: 27.75
+	Mm
		936473 WASP_MOUSE (17-487): 1.16e-101: 316: 86.04		NCK1_MOUSE (889-1057): 2.15e-09: 63.5: 28.49
+	Hs
		557631 WASP_HUMAN (1-487): 8.09e-99: 308: 100.00		NCK1_HUMAN (895-1055): 6.44e-09: 62: 27.75
+	Dm
		112580 Q9VAT0_DROME (13-324): 3.69e-84: 271: 35.98		M9ND00_DROME (713-1252): 3.91e-15: 83.6: 12.73
+	Dm
		1361426 Q9VAT0_DROME (13-324): 3.69e-84: 271: 35.98		Q9VIF7_DROME (709-1252): 6.76e-15: 82.8: 12.46
+	Rn
		1126747 SYNJ1_RAT (62-495): 7.56e-37: 147: 13.28		Q5JC29_RAT (529-841): 5.46e-10: 66.6: 12.00
+	Hs
		855816 TITIN_HUMAN (216-486): 6.08e-22: 102: 14.39		VAV2_HUMAN (612-1210): 1.5e-14: 81.3: 11.88
+	Hs
		787872 DYN2_HUMAN (244-438): 9.39e-25: 110: 17.54		EPS15_HUMAN (529-913): 1.04e-10: 68.9: 12.69
+	Hs
		840719 DYN2_HUMAN (244-438): 9.39e-25: 110: 17.54		SH319_HUMAN (1079-1218): 3.12e-09: 63.9: 28.57
+	Hs
		557664 DYN1_HUMAN (268-428): 5.28e-19: 92.7: 18.01		NCK1_HUMAN (895-1055): 6.44e-09: 62: 27.75