HitPredict

Interactor 1: CDN2A (P42771)
Cyclin-dependent kinase inhibitor 2A (Cyclin-dependent kinase 4 inhibitor A) (CDK4I) (Multiple tumor suppressor 1) (MTS-1) (p16-INK4a) (p16-INK4) (p16INK4A)
Gene: CDKN2A

Interactor 2: CDC42 (P60953)
Cell division control protein 42 homolog (EC 3.6.5.2) (G25K GTP-binding protein)
Gene: CDC42

Species: Homo sapiens

Source: biogrid

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.58	0.60	0.595

Property	Details
Experiments	31478661, 31871319
Identification Methods	pull down, affinity chromatography technology
Interaction Type	direct interaction, physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005737 - cytoplasm GO:0005829 - cytosol GO:0019901 - protein kinase binding
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 156 Hs			1 191
+	Hs
		790878 CDN2A_HUMAN (1-156): 1.38e-51: 163: 100.00		RHOJ_HUMAN (2-188): 2.67e-85: 252: 64.17
+	Hs
		790746 CDN2A_HUMAN (1-156): 1.38e-51: 163: 100.00		RHOG_HUMAN (1-191): 7.59e-82: 242: 60.73
+	Hs
		790732 CDN2A_HUMAN (1-156): 1.38e-51: 163: 100.00		RHOA_HUMAN (5-191): 3.88e-81: 240: 53.48
+	Hs
		545247 CDN2A_HUMAN (1-156): 1.38e-51: 163: 100.00		RAC2_HUMAN (1-191): 1.49e-80: 239: 68.75
+	Hs
		790729 CDN2A_HUMAN (1-156): 1.38e-51: 163: 100.00		RAC3_HUMAN (1-177): 2.36e-78: 233: 72.32
+	Hs
		564741 ANR26_HUMAN (2-155): 9.25e-33: 123: 18.59		RHOQ_HUMAN (4-187): 7.35e-91: 266: 67.94
+	Hs
		925204 ANK2_HUMAN (3-155): 1.76e-37: 137: 17.37		RAC1_HUMAN (1-191): 1.75e-84: 249: 70.31
+	Hs
		925238 ANK3_HUMAN (15-155): 1.26e-35: 132: 21.13		RAC1_HUMAN (1-191): 1.75e-84: 249: 70.31
+	Hs
		1330992 ANR26_HUMAN (2-155): 9.25e-33: 123: 18.59		RHOJ_HUMAN (2-188): 2.67e-85: 252: 64.17
+	Hs
		893947 ANK3_HUMAN (15-155): 1.26e-35: 132: 21.13		CDC42_HUMAN (1-191): 4.96e-82: 243: 100.00
+	Hs
		950953 ANK3_HUMAN (15-155): 1.26e-35: 132: 21.13		RHOG_HUMAN (1-191): 7.59e-82: 242: 60.73
+	Hs
		900423 ANK3_HUMAN (15-155): 1.26e-35: 132: 21.13		RHOA_HUMAN (5-191): 3.88e-81: 240: 53.48
+	Hs
		925737 ANR26_HUMAN (2-155): 9.25e-33: 123: 18.59		RAC1_HUMAN (1-191): 1.75e-84: 249: 70.31
+	Hs
		894594 ANR26_HUMAN (2-155): 9.25e-33: 123: 18.59		CDC42_HUMAN (1-191): 4.96e-82: 243: 100.00
+	Hs
		951461 ANR26_HUMAN (2-155): 9.25e-33: 123: 18.59		RHOG_HUMAN (1-191): 7.59e-82: 242: 60.73
+	Hs
		901057 ANR26_HUMAN (2-155): 9.25e-33: 123: 18.59		RHOA_HUMAN (5-191): 3.88e-81: 240: 53.48
+	Hs
		436576 ANR26_HUMAN (2-155): 9.25e-33: 123: 18.59		RHOC_HUMAN (5-191): 3.64e-79: 235: 52.41
+	Hs
		892683 ANR26_HUMAN (2-155): 9.25e-33: 123: 18.59		RAC3_HUMAN (1-177): 2.36e-78: 233: 72.32
+	Hs
		1021421 ANK3_HUMAN (15-155): 1.26e-35: 132: 21.13		RHOU_HUMAN (4-186): 1.03e-72: 221: 58.82
+	Hs
		1183613 ANR26_HUMAN (2-155): 9.25e-33: 123: 18.59		RHOU_HUMAN (4-186): 1.03e-72: 221: 58.82