HitPredict

Interactor 1: CDN2A (P42771)
Cyclin-dependent kinase inhibitor 2A (Cyclin-dependent kinase 4 inhibitor A) (CDK4I) (Multiple tumor suppressor 1) (MTS-1) (p16-INK4a) (p16-INK4) (p16INK4A)
Gene: CDKN2A

Interactor 2: ACTG (P63261)
Actin, cytoplasmic 2 (EC 3.6.4.-) (Gamma-actin) [Cleaved into: Actin, cytoplasmic 2, N-terminally processed]
Gene: ACTG1

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.44	0.60	0.516

Property	Details
Experiments	17955473
Identification Methods	pull down
Interaction Type	direct interaction, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005634 - nucleus GO:0005737 - cytoplasm GO:0005829 - cytosol GO:0019901 - protein kinase binding
Homologous interactions	17

Homologous interactions

Color coding for hit scores

	1 156 Hs			1 375
+	Hs
		965115 ANK2_HUMAN (3-155): 1.76e-37: 137: 17.37		ACTBL_HUMAN (2-375): 0: 734: 91.44
+	Hs
		60342 POTEF_HUMAN (1-130): 1.26e-29: 115: 19.55		ACTBL_HUMAN (2-375): 0: 734: 91.44
+	Hs
		790728 CDN2A_HUMAN (1-156): 1.38e-51: 163: 100.00		ACTB_HUMAN (1-375): 0: 604: 98.93
+	Hs
		891699 ANK2_HUMAN (3-155): 1.76e-37: 137: 17.37		ACTB_HUMAN (1-375): 0: 604: 98.93
+	Rn
		251023 ANK3_RAT (15-155): 2.98e-33: 125: 20.67		ACTB_RAT (1-375): 0: 604: 98.93
+	Hs
		930079 ANK2_HUMAN (3-155): 1.76e-37: 137: 17.37		ACTH_HUMAN (2-375): 0: 592: 94.39
+	Hs
		60318 POTEF_HUMAN (1-130): 1.26e-29: 115: 19.55		ACTC_HUMAN (2-375): 0: 595: 94.39
+	Hs
		891932 CTTB2_HUMAN (1-151): 1.02e-22: 95.1: 21.25		ACTB_HUMAN (1-375): 0: 604: 98.93
+	Hs
		474804 POTEI_HUMAN (49-152): 1.58e-18: 83.1: 13.89		ACTB_HUMAN (1-375): 0: 604: 98.93
+	Hs
		474872 POTEJ_HUMAN (49-152): 1.44e-18: 83.1: 13.89		ACTB_HUMAN (1-375): 0: 604: 98.93
+	Hs
		891845 POTEE_HUMAN (49-152): 2.11e-18: 82.7: 14.82		ACTB_HUMAN (1-375): 0: 604: 98.93
+	Hs
		929902 POTEE_HUMAN (49-152): 2.11e-18: 82.7: 14.82		ACTG_HUMAN (1-375): 0: 604: 100.00
+	Hs
		891882 ANKH1_HUMAN (68-155): 3.32e-18: 82.3: 19.32		ACTB_HUMAN (1-375): 0: 604: 98.93
+	Hs
		474805 POTEI_HUMAN (49-152): 1.58e-18: 83.1: 13.89		ACTC_HUMAN (2-375): 0: 595: 94.39
+	Hs
		474874 POTEJ_HUMAN (49-152): 1.44e-18: 83.1: 13.89		ACTC_HUMAN (2-375): 0: 595: 94.39
+	Hs
		862022 DAPK1_HUMAN (49-155): 4.06e-14: 70.4: 22.02		ACTC_HUMAN (2-375): 0: 595: 94.39
+	Hs
		932420 RAI14_HUMAN (1-64): 1.97e-11: 62.7: 21.21		ACTC_HUMAN (2-375): 0: 595: 94.39