HitPredict

Interactor 1: CDN2A (P42771)
Cyclin-dependent kinase inhibitor 2A (Cyclin-dependent kinase 4 inhibitor A) (CDK4I) (Multiple tumor suppressor 1) (MTS-1) (p16-INK4a) (p16-INK4) (p16INK4A)
Gene: CDKN2A

Interactor 2: RHOG (P84095)
Rho-related GTP-binding protein RhoG
Gene: RHOG

Species: Homo sapiens

Source: biogrid

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.38	0.60	0.479

Property	Details
Experiments	31871319
Identification Methods	affinity chromatography technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005829 - cytosol GO:0019901 - protein kinase binding
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 156 Hs			1 191
+	Hs
		545247 CDN2A_HUMAN (1-156): 1.38e-51: 163: 100.00		RAC2_HUMAN (1-191): 1.28e-78: 234: 71.35
+	Hs
		790730 CDN2A_HUMAN (1-156): 1.38e-51: 163: 100.00		CDC42_HUMAN (1-191): 1.3e-78: 234: 60.73
+	Hs
		790732 CDN2A_HUMAN (1-156): 1.38e-51: 163: 100.00		RHOA_HUMAN (5-191): 1.26e-78: 234: 55.62
+	Hs
		790729 CDN2A_HUMAN (1-156): 1.38e-51: 163: 100.00		RAC3_HUMAN (1-177): 1.67e-75: 226: 72.88
+	Hs
		925204 ANK2_HUMAN (3-155): 1.76e-37: 137: 17.37		RAC1_HUMAN (1-191): 3.6e-82: 243: 71.88
+	Hs
		925238 ANK3_HUMAN (15-155): 1.26e-35: 132: 21.13		RAC1_HUMAN (1-191): 3.6e-82: 243: 71.88
+	Hs
		950953 ANK3_HUMAN (15-155): 1.26e-35: 132: 21.13		RHOG_HUMAN (1-191): 9.12e-82: 242: 100.00
+	Hs
		893947 ANK3_HUMAN (15-155): 1.26e-35: 132: 21.13		CDC42_HUMAN (1-191): 1.3e-78: 234: 60.73
+	Hs
		900423 ANK3_HUMAN (15-155): 1.26e-35: 132: 21.13		RHOA_HUMAN (5-191): 1.26e-78: 234: 55.62
+	Hs
		925737 ANR26_HUMAN (2-155): 9.25e-33: 123: 18.59		RAC1_HUMAN (1-191): 3.6e-82: 243: 71.88
+	Hs
		951461 ANR26_HUMAN (2-155): 9.25e-33: 123: 18.59		RHOG_HUMAN (1-191): 9.12e-82: 242: 100.00
+	Hs
		894594 ANR26_HUMAN (2-155): 9.25e-33: 123: 18.59		CDC42_HUMAN (1-191): 1.3e-78: 234: 60.73
+	Hs
		901057 ANR26_HUMAN (2-155): 9.25e-33: 123: 18.59		RHOA_HUMAN (5-191): 1.26e-78: 234: 55.62
+	Hs
		436576 ANR26_HUMAN (2-155): 9.25e-33: 123: 18.59		RHOC_HUMAN (5-191): 8.34e-77: 230: 56.15
+	Hs
		883465 RIPK4_HUMAN (9-155): 1.21e-30: 117: 25.68		RHOA_HUMAN (5-191): 1.26e-78: 234: 55.62
+	Hs
		900896 Q9H4D1_HUMAN (9-155): 2.04e-30: 116: 25.68		RHOA_HUMAN (5-191): 1.26e-78: 234: 55.62
+	Hs
		892683 ANR26_HUMAN (2-155): 9.25e-33: 123: 18.59		RAC3_HUMAN (1-177): 1.67e-75: 226: 72.88
+	Hs
		564741 ANR26_HUMAN (2-155): 9.25e-33: 123: 18.59		RHOQ_HUMAN (4-189): 5.74e-73: 220: 56.84
+	Hs
		545454 POTEE_HUMAN (49-152): 2.11e-18: 82.7: 14.82		RAC2_HUMAN (1-191): 1.28e-78: 234: 71.35
+	Hs
		892579 TANC1_HUMAN (56-154): 1.3e-14: 71.9: 21.00		RAC3_HUMAN (1-177): 1.67e-75: 226: 72.88