Interactor 1: CDN2A (P42771)
Cyclin-dependent kinase inhibitor 2A (Cyclin-dependent kinase 4 inhibitor A) (CDK4I) (Multiple tumor suppressor 1) (MTS-1) (p16-INK4a) (p16-INK4) (p16INK4A)
Gene: CDKN2A
Interactor 2: MDM2 (Q00987)
E3 ubiquitin-protein ligase Mdm2 (EC 2.3.2.27) (Double minute 2 protein) (Hdm2) (Oncoprotein Mdm2) (RING-type E3 ubiquitin transferase Mdm2) (p53-binding protein Mdm2)
Gene: MDM2
Species: Homo sapiens
Source: biogrid
Category: Small-scale
Confidence: High
| Method score | Annotation score | Interaction score |
|---|---|---|
| 0.98 | 0.60 | 0.769 |
The method score is based on:
| Property | Details |
|---|---|
| Experiments | 25809483, 14612427, 16702947, 22467867, 28205554, 9529249, 12085228, 9529248, 18583933, 35944929, 16107876, 11223036, 10822382, 20395212, 22120712, 18541670, 17116689, 10801444, 16173922, 18813780 and 15 others
more... |
| Identification Methods | affinity chromatography technology, fluorescent resonance energy transfer, pull down, unspecified method, two hybrid |
| Interaction Type | physical association, direct interaction |
The annotation score is based on:
| Property | Details |
|---|---|
| Interacting Pfam domains | - |
| Common GO terms | GO:0005634 - nucleus GO:0005737 - cytoplasm GO:0005829 - cytosol GO:0045892 - negative regulation of DNA-templated transcription GO:0051726 - regulation of cell cycle |
| Homologous interactions | 7 |
Homologous interactions
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Service provided by Combinatics, Japan
Last updated: 15 Jul 2024
