HitPredict

Interactor 1: CDN2A (P42771)
Cyclin-dependent kinase inhibitor 2A (Cyclin-dependent kinase 4 inhibitor A) (CDK4I) (Multiple tumor suppressor 1) (MTS-1) (p16-INK4a) (p16-INK4) (p16INK4A)
Gene: CDKN2A

Interactor 2: EP300 (Q09472)
Histone acetyltransferase p300 (p300 HAT) (EC 2.3.1.48) (E1A-associated protein p300) (Histone butyryltransferase p300) (EC 2.3.1.-) (Histone crotonyltransferase p300) (EC 2.3.1.-) (Protein 2-hydroxyisobutyryltransferase p300) (EC 2.3.1.-) (Protein lactyltransferas p300) (EC 2.3.1.-) (Protein propionyltransferase p300) (EC 2.3.1.-)
Gene: EP300

Species: Homo sapiens

Source: innatedb

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.56	0.60	0.584

Property	Details
Experiments	30110629, 15286281
Identification Methods	affinity chromatography technology, anti tag coimmunoprecipitation
Interaction Type	physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005634 - nucleus GO:0005737 - cytoplasm GO:0005829 - cytosol GO:0007049 - cell cycle GO:0051059 - NF-kappaB binding
Homologous interactions	17

Homologous interactions

Color coding for hit scores

	1 156 Hs			1 2414
+	Hs
		790925 CDN2B_HUMAN (3-136): 4.71e-52: 163: 81.34		EP300_HUMAN (1-2414): 0: 1113: 100.00
+	Hs
		556698 ANK1_HUMAN (2-130): 2.4e-33: 125: 24.62		EP300_HUMAN (1-2414): 0: 1113: 100.00
+	Hs
		276174 PSD10_HUMAN (1-85): 4.57e-12: 63.1: 23.86		EP300_HUMAN (1-2414): 0: 1113: 100.00
+	Mm
		877466 CDN2B_MOUSE (11-136): 3.98e-53: 166: 85.71		TRI33_MOUSE (604-1201): 4.87e-41: 168: 14.81
+	Hs
		631594 EHMT1_HUMAN (4-121): 1.19e-30: 117: 19.33		BRD2_HUMAN (1035-1159): 9.57e-30: 131: 31.20
+	Hs
		1067147 EHMT1_HUMAN (4-121): 1.19e-30: 117: 19.33		BRD3_HUMAN (1055-1159): 9.06e-30: 130: 30.48
+	Hs
		631553 EHMT2_HUMAN (4-114): 3.84e-29: 113: 24.11		BRD2_HUMAN (1035-1159): 9.57e-30: 131: 31.20
+	Hs
		1067098 EHMT2_HUMAN (4-114): 3.84e-29: 113: 24.11		BRD3_HUMAN (1055-1159): 9.06e-30: 130: 30.48
+	Hs
		167045 ANR28_HUMAN (82-155): 3.69e-09: 56.1: 16.22		TRI33_HUMAN (604-1201): 1.37e-44: 180: 14.50
+	Hs
		164325 ANR28_HUMAN (82-155): 3.69e-09: 56.1: 16.22		TRI66_HUMAN (268-1197): 1.08e-40: 168: 12.26
+	Hs
		631580 TANC1_HUMAN (56-154): 1.3e-14: 71.9: 21.00		BRD2_HUMAN (1035-1159): 9.57e-30: 131: 31.20
+	Hs
		257668 ANR17_HUMAN (69-147): 2.99e-19: 85.1: 20.25		PHIP_HUMAN (1068-1157): 6.78e-12: 73.6: 42.86
+	Hs
		1219797 ANKH1_HUMAN (68-155): 3.32e-18: 82.3: 19.32		PHIP_HUMAN (1068-1157): 6.78e-12: 73.6: 42.86
+	Hs
		310053 TNKS1_HUMAN (49-142): 1.94e-13: 68.6: 25.26		MDC1_HUMAN (455-1061): 8.69e-13: 76.6: 11.82
+	Hs
		1056981 TNKS2_HUMAN (8-136): 1.5e-11: 63.2: 21.05		MDC1_HUMAN (455-1061): 8.69e-13: 76.6: 11.82
+	Hs
		1057007 RAI14_HUMAN (1-64): 1.97e-11: 62.7: 21.21		MDC1_HUMAN (455-1061): 8.69e-13: 76.6: 11.82
+	Hs
		276200 PSD10_HUMAN (1-85): 4.57e-12: 63.1: 23.86		CBP_HUMAN (1752-2400): 4.44e-10: 67.9: 13.25