HitPredict

Interactor 1: CDN2A (P42771)
Cyclin-dependent kinase inhibitor 2A (Cyclin-dependent kinase 4 inhibitor A) (CDK4I) (Multiple tumor suppressor 1) (MTS-1) (p16-INK4a) (p16-INK4) (p16INK4A)
Gene: CDKN2A

Interactor 2: TIF1B (Q13263)
Transcription intermediary factor 1-beta (TIF1-beta) (E3 SUMO-protein ligase TRIM28) (EC 2.3.2.27) (KRAB-associated protein 1) (KAP-1) (KRAB-interacting protein 1) (KRIP-1) (Nuclear corepressor KAP-1) (RING finger protein 96) (RING-type E3 ubiquitin transferase TIF1-beta) (Tripartite motif-containing protein 28)
Gene: TRIM28

Species: Homo sapiens

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.52	0.60	0.561

Property	Details
Experiments	26055329
Identification Methods	affinity chromatography technology, pull down
Interaction Type	physical association, direct interaction

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0003723 - RNA binding GO:0005634 - nucleus GO:0045892 - negative regulation of DNA-templated transcription
Homologous interactions	17

Homologous interactions

Color coding for hit scores

	1 156 Hs			1 835
+	Hs
		1029886 EHMT1_HUMAN (4-121): 1.19e-30: 117: 19.33		TIF1B_HUMAN (18-835): 3.77e-174: 525: 100.00
+	Hs
		1029752 EHMT2_HUMAN (4-114): 3.84e-29: 113: 24.11		TIF1B_HUMAN (18-835): 3.77e-174: 525: 100.00
+	Hs
		257607 ANR17_HUMAN (69-147): 2.99e-19: 85.1: 20.25		TIF1B_HUMAN (18-835): 3.77e-174: 525: 100.00
+	Hs
		1029611 ANKH1_HUMAN (68-155): 3.32e-18: 82.3: 19.32		TIF1B_HUMAN (18-835): 3.77e-174: 525: 100.00
+	Hs
		668494 CDN2A_HUMAN (1-156): 1.38e-51: 163: 100.00		PML_HUMAN (29-609): 1.21e-57: 214: 14.00
+	Mm
		877466 CDN2B_MOUSE (11-136): 3.98e-53: 166: 85.71		TRI33_MOUSE (406-826): 4.38e-52: 199: 18.41
+	Hs
		668548 CDN2D_HUMAN (12-134): 6.5e-45: 146: 49.19		PML_HUMAN (29-609): 1.21e-57: 214: 14.00
+	Hs
		668912 EHMT2_HUMAN (4-114): 3.84e-29: 113: 24.11		PML_HUMAN (29-609): 1.21e-57: 214: 14.00
+	Hs
		110742 POTB2_HUMAN (1-152): 3.54e-29: 113: 19.87		TRI23_HUMAN (38-421): 2.37e-56: 205: 14.42
+	Hs
		2053 POTEB_HUMAN (1-152): 3.54e-29: 113: 19.87		TRI23_HUMAN (38-421): 2.37e-56: 205: 14.42
+	Hs
		1071512 ANKR1_HUMAN (47-155): 1.2e-17: 79.2: 21.10		TRI63_HUMAN (53-406): 8.26e-61: 211: 15.56
+	Hs
		170182 ANR17_HUMAN (69-147): 2.99e-19: 85.1: 20.25		TIF1A_HUMAN (404-808): 1.31e-52: 200: 21.55
+	Hs
		170416 ANKH1_HUMAN (68-155): 3.32e-18: 82.3: 19.32		TIF1A_HUMAN (404-808): 1.31e-52: 200: 21.55
+	Hs
		170470 TANC1_HUMAN (56-154): 1.3e-14: 71.9: 21.00		TIF1A_HUMAN (404-808): 1.31e-52: 200: 21.55
+	Hs
		1071515 ANKR1_HUMAN (47-155): 1.2e-17: 79.2: 21.10		TRI55_HUMAN (41-610): 9.71e-50: 186: 14.21
+	Hs
		167045 ANR28_HUMAN (82-155): 3.69e-09: 56.1: 16.22		TRI33_HUMAN (406-826): 1.6e-54: 206: 19.32
+	Hs
		164325 ANR28_HUMAN (82-155): 3.69e-09: 56.1: 16.22		TRI66_HUMAN (335-810): 2.93e-45: 178: 19.00