HitPredict

Interactor 1: CDN2A (P42771)
Cyclin-dependent kinase inhibitor 2A (Cyclin-dependent kinase 4 inhibitor A) (CDK4I) (Multiple tumor suppressor 1) (MTS-1) (p16-INK4a) (p16-INK4) (p16INK4A)
Gene: CDKN2A

Interactor 2: EZH2 (Q15910)
Histone-lysine N-methyltransferase EZH2 (EC 2.1.1.356) (ENX-1) (Enhancer of zeste homolog 2) (Lysine N-methyltransferase 6)
Gene: EZH2

Species: Homo sapiens

Source: innatedb

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.38	0.60	0.479

Property	Details
Experiments	25955299
Identification Methods	anti tag coimmunoprecipitation
Interaction Type	physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005634 - nucleus GO:0045892 - negative regulation of DNA-templated transcription
Homologous interactions	17

Homologous interactions

Color coding for hit scores

	1 156 Hs			1 746
+	Hs
		1080355 EHMT1_HUMAN (4-121): 1.19e-30: 117: 19.33		EZH2_HUMAN (1-746): 0: 862: 100.00
+	Mm
		1125426 EHMT1_MOUSE (4-119): 1.01e-30: 118: 20.51		EZH2_MOUSE (1-746): 0: 860: 98.39
+	Hs
		1080244 EHMT2_HUMAN (4-114): 3.84e-29: 113: 24.11		EZH2_HUMAN (1-746): 0: 862: 100.00
+	Hs
		790980 CDN2C_HUMAN (21-135): 1.37e-25: 97.4: 28.21		EZH2_HUMAN (1-746): 0: 862: 100.00
+	Hs
		1080047 POTEE_HUMAN (49-152): 2.11e-18: 82.7: 14.82		EZH2_HUMAN (1-746): 0: 862: 100.00
+	Hs
		166937 ANR28_HUMAN (82-155): 3.69e-09: 56.1: 16.22		EZH2_HUMAN (1-746): 0: 862: 100.00
+	Mm
		936645 EHMT1_MOUSE (4-119): 1.01e-30: 118: 20.51		EZH1_MOUSE (15-745): 0: 755: 63.61
+	Hs
		790870 CDN2A_HUMAN (1-156): 1.38e-51: 163: 100.00		NSD3_HUMAN (275-729): 9.41e-70: 251: 14.42
+	Hs
		1334130 EHMT1_HUMAN (4-121): 1.19e-30: 117: 19.33		EHMT1_HUMAN (441-732): 1.73e-70: 253: 24.27
+	Mm
		1125434 EHMT1_MOUSE (4-119): 1.01e-30: 118: 20.51		EHMT2_MOUSE (467-732): 2.28e-68: 247: 24.56
+	Hs
		1296421 EHMT1_HUMAN (4-121): 1.19e-30: 117: 19.33		EHMT2_HUMAN (467-732): 1.91e-68: 247: 24.21
+	Hs
		1331975 EHMT1_HUMAN (4-121): 1.19e-30: 117: 19.33		SUV92_HUMAN (447-734): 5.41e-74: 247: 24.10
+	Hs
		1296396 EHMT2_HUMAN (4-114): 3.84e-29: 113: 24.11		EHMT2_HUMAN (467-732): 1.91e-68: 247: 24.21
+	Hs
		1296419 EHMT2_HUMAN (4-114): 3.84e-29: 113: 24.11		SUV92_HUMAN (447-734): 5.41e-74: 247: 24.10
+	Hs
		203794 EHMT1_HUMAN (4-121): 1.19e-30: 117: 19.33		SUV91_HUMAN (354-731): 2.25e-71: 240: 19.90
+	Hs
		203766 EHMT2_HUMAN (4-114): 3.84e-29: 113: 24.11		SUV91_HUMAN (354-731): 2.25e-71: 240: 19.90
+	Hs
		166998 ANR28_HUMAN (82-155): 3.69e-09: 56.1: 16.22		EHMT2_HUMAN (467-732): 1.91e-68: 247: 24.21