HitPredict

Interactor 1: CDN2A (P42771)
Cyclin-dependent kinase inhibitor 2A (Cyclin-dependent kinase 4 inhibitor A) (CDK4I) (Multiple tumor suppressor 1) (MTS-1) (p16-INK4a) (p16-INK4) (p16INK4A)
Gene: CDKN2A

Interactor 2: NSD3 (Q9BZ95)
Histone-lysine N-methyltransferase NSD3 (EC 2.1.1.370) (EC 2.1.1.371) (Nuclear SET domain-containing protein 3) (Protein whistle) (WHSC1-like 1 isoform 9 with methyltransferase activity to lysine) (Wolf-Hirschhorn syndrome candidate 1-like protein 1) (WHSC1-like protein 1)
Gene: NSD3

Species: Homo sapiens

Source: mint

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.48	0.60	0.541

Property	Details
Experiments	25640309
Identification Methods	two hybrid, two hybrid array
Interaction Type	direct interaction, physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005634 - nucleus
Homologous interactions	16

Homologous interactions

Color coding for hit scores

	1 156 Hs			1 1437
+	Hs
		1331975 EHMT1_HUMAN (4-121): 1.19e-30: 117: 19.33		SUV92_HUMAN (903-1285): 1.04e-77: 265: 23.22
+	Hs
		790790 CDN2A_HUMAN (1-156): 1.38e-51: 163: 100.00		EZH2_HUMAN (1076-1270): 1.53e-58: 218: 28.78
+	Hs
		1296419 EHMT2_HUMAN (4-114): 3.84e-29: 113: 24.11		SUV92_HUMAN (903-1285): 1.04e-77: 265: 23.22
+	Hs
		203794 EHMT1_HUMAN (4-121): 1.19e-30: 117: 19.33		SUV91_HUMAN (904-1285): 4e-73: 252: 22.56
+	Hs
		203766 EHMT2_HUMAN (4-114): 3.84e-29: 113: 24.11		SUV91_HUMAN (904-1285): 4e-73: 252: 22.56
+	Hs
		1296421 EHMT1_HUMAN (4-121): 1.19e-30: 117: 19.33		EHMT2_HUMAN (1029-1281): 2.28e-60: 229: 22.84
+	Hs
		1334130 EHMT1_HUMAN (4-121): 1.19e-30: 117: 19.33		EHMT1_HUMAN (995-1301): 1.89e-59: 227: 20.54
+	Hs
		1296396 EHMT2_HUMAN (4-114): 3.84e-29: 113: 24.11		EHMT2_HUMAN (1029-1281): 2.28e-60: 229: 22.84
+	Mm
		936645 EHMT1_MOUSE (4-119): 1.01e-30: 118: 20.51		EZH1_MOUSE (1076-1270): 3.93e-59: 220: 30.24
+	Mm
		1125426 EHMT1_MOUSE (4-119): 1.01e-30: 118: 20.51		EZH2_MOUSE (1076-1270): 1.26e-58: 218: 28.78
+	Hs
		1080355 EHMT1_HUMAN (4-121): 1.19e-30: 117: 19.33		EZH2_HUMAN (1076-1270): 1.53e-58: 218: 28.78
+	Hs
		1080244 EHMT2_HUMAN (4-114): 3.84e-29: 113: 24.11		EZH2_HUMAN (1076-1270): 1.53e-58: 218: 28.78
+	Hs
		790980 CDN2C_HUMAN (21-135): 1.37e-25: 97.4: 28.21		EZH2_HUMAN (1076-1270): 1.53e-58: 218: 28.78
+	Hs
		1080047 POTEE_HUMAN (49-152): 2.11e-18: 82.7: 14.82		EZH2_HUMAN (1076-1270): 1.53e-58: 218: 28.78
+	Hs
		166998 ANR28_HUMAN (82-155): 3.69e-09: 56.1: 16.22		EHMT2_HUMAN (1029-1281): 2.28e-60: 229: 22.84
+	Hs
		166937 ANR28_HUMAN (82-155): 3.69e-09: 56.1: 16.22		EZH2_HUMAN (1076-1270): 1.53e-58: 218: 28.78