HitPredict

Interactor 1: CDN2C (P42773)
Cyclin-dependent kinase 4 inhibitor C (Cyclin-dependent kinase 6 inhibitor) (p18-INK4c) (p18-INK6)
Gene: CDKN2C

Interactor 2: MK08 (P45983)
Mitogen-activated protein kinase 8 (MAP kinase 8) (MAPK 8) (EC 2.7.11.24) (JNK-46) (Stress-activated protein kinase 1c) (SAPK1c) (Stress-activated protein kinase JNK1) (c-Jun N-terminal kinase 1)
Gene: MAPK8

Species: Homo sapiens

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.41	1.00	0.647

Property	Details
Experiments	16007099
Identification Methods	pull down
Interaction Type	direct interaction

Property	Details
Interacting Pfam domains	Ank_2~Pkinase, Ank_4~Pkinase
Common GO terms	GO:0005634 - nucleus GO:0005737 - cytoplasm GO:0005829 - cytosol
Homologous interactions	15

Homologous interactions

Color coding for hit scores

	1 168 Hs			1 427
+	Hs
		790960 CDN2C_HUMAN (1-168): 3.27e-53: 168: 100.00		MK10_HUMAN (1-427): 6.5e-163: 468: 90.16
+	Hs
		790703 CDN2A_HUMAN (3-140): 5.49e-22: 88.2: 39.57		MK08_HUMAN (1-427): 6.2e-164: 469: 100.00
+	Hs
		790718 CDN2A_HUMAN (3-140): 5.49e-22: 88.2: 39.57		MK10_HUMAN (1-427): 6.5e-163: 468: 90.16
+	Hs
		625621 RAI14_HUMAN (1-135): 3.41e-37: 136: 21.32		CDK2_HUMAN (23-329): 1.82e-136: 394: 33.23
+	Hs
		790791 CDN2A_HUMAN (3-140): 5.49e-22: 88.2: 39.57		MK14_HUMAN (4-365): 2.33e-130: 381: 46.03
+	Mm
		814053 MIB1_MOUSE (74-168): 3.38e-14: 71.1: 21.88		MK14_MOUSE (4-365): 9.55e-131: 382: 46.03
+	Hs
		658832 CDN2C_HUMAN (1-168): 3.27e-53: 168: 100.00		MK01_HUMAN (20-359): 2.94e-84: 263: 42.98
+	Hs
		658871 CDN2D_HUMAN (6-159): 4e-48: 155: 45.81		MK01_HUMAN (20-359): 2.94e-84: 263: 42.98
+	Rn
		926518 CSKI1_RAT (1-159): 7.2e-30: 116: 14.69		MK01_RAT (20-359): 2.95e-84: 263: 42.98
+	Hs
		658865 DAPK1_HUMAN (42-168): 1.97e-29: 114: 20.93		MK01_HUMAN (20-359): 2.94e-84: 263: 42.98
+	Hs
		647524 DAPK1_HUMAN (42-168): 1.97e-29: 114: 20.93		MK03_HUMAN (20-359): 5.22e-83: 261: 41.26
+	Hs
		658830 CDN2A_HUMAN (3-140): 5.49e-22: 88.2: 39.57		MK01_HUMAN (20-359): 2.94e-84: 263: 42.98
+	Hs
		647496 CDN2A_HUMAN (3-140): 5.49e-22: 88.2: 39.57		MK03_HUMAN (20-359): 5.22e-83: 261: 41.26
+	Hs
		658831 CDN2B_HUMAN (9-122): 1.23e-20: 84: 45.22		MK01_HUMAN (20-359): 2.94e-84: 263: 42.98
+	Rn
		926505 TANC1_RAT (82-168): 3.37e-12: 65.4: 22.47		MK01_RAT (20-359): 2.95e-84: 263: 42.98