HitPredict

Interactor 1: CDN2C (P42773)
Cyclin-dependent kinase 4 inhibitor C (Cyclin-dependent kinase 6 inhibitor) (p18-INK4c) (p18-INK6)
Gene: CDKN2C

Interactor 2: MP2K3 (P46734)
Dual specificity mitogen-activated protein kinase kinase 3 (MAP kinase kinase 3) (MAPKK 3) (EC 2.7.12.2) (MAPK/ERK kinase 3) (MEK 3) (Stress-activated protein kinase kinase 2) (SAPK kinase 2) (SAPKK-2) (SAPKK2)
Gene: MAP2K3

Species: Homo sapiens

Source: biogrid

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.41	1.00	0.647

Property	Details
Experiments	28205554
Identification Methods	fluorescent resonance energy transfer
Interaction Type	direct interaction

Property	Details
Interacting Pfam domains	Ank_2~Pkinase, Ank_4~Pkinase
Common GO terms	GO:0005737 - cytoplasm GO:0005829 - cytosol GO:0019901 - protein kinase binding
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 168 Hs			1 347
+	Hs
		681718 CDN2C_HUMAN (1-168): 3.27e-53: 168: 100.00		AKT1_HUMAN (36-345): 1.71e-127: 375: 20.76
+	Rn
		1144333 CSKI1_RAT (1-159): 7.2e-30: 116: 14.69		AKT3_RAT (24-345): 3.98e-124: 366: 20.91
+	Hs
		647851 DAPK1_HUMAN (42-168): 1.97e-29: 114: 20.93		MARK3_HUMAN (8-344): 6.23e-120: 364: 19.53
+	Hs
		862065 DAPK1_HUMAN (42-168): 1.97e-29: 114: 20.93		MARK2_HUMAN (8-344): 2.1e-119: 364: 20.41
+	Hs
		625621 RAI14_HUMAN (1-135): 3.41e-37: 136: 21.32		CDK2_HUMAN (61-336): 3.55e-114: 335: 23.43
+	Hs
		623870 RIPK4_HUMAN (1-99): 1.47e-26: 106: 28.00		KPCL_HUMAN (22-344): 3.41e-119: 360: 19.58
+	Hs
		681716 CDN2A_HUMAN (3-140): 5.49e-22: 88.2: 39.57		AKT1_HUMAN (36-345): 1.71e-127: 375: 20.76
+	Hs
		681717 CDN2B_HUMAN (9-122): 1.23e-20: 84: 45.22		AKT1_HUMAN (36-345): 1.71e-127: 375: 20.76
+	Hs
		160716 EHMT2_HUMAN (3-143): 9.16e-45: 158: 34.27		AURKA_HUMAN (1-334): 5.44e-97: 294: 24.70
+	Hs
		790917 CDN2B_HUMAN (9-122): 1.23e-20: 84: 45.22		MP2K3_HUMAN (1-347): 1.73e-124: 362: 100.00
+	Hs
		257579 ANR17_HUMAN (3-166): 2.37e-18: 83: 20.10		MP2K3_HUMAN (1-347): 1.73e-124: 362: 100.00
+	Hs
		790918 CDN2B_HUMAN (9-122): 1.23e-20: 84: 45.22		MP2K6_HUMAN (12-345): 3.22e-121: 354: 79.04
+	Hs
		883501 RIPK4_HUMAN (1-99): 1.47e-26: 106: 28.00		STK3_HUMAN (30-345): 2.05e-102: 311: 33.86
+	Hs
		790970 CDN2C_HUMAN (1-168): 3.27e-53: 168: 100.00		MP2K5_HUMAN (56-324): 7.89e-66: 216: 45.09
+	Hs
		160430 CDN2A_HUMAN (3-140): 5.49e-22: 88.2: 39.57		AURKA_HUMAN (1-334): 5.44e-97: 294: 24.70
+	Hs
		160648 MIB1_HUMAN (74-168): 4.43e-14: 70.7: 21.88		AURKA_HUMAN (1-334): 5.44e-97: 294: 24.70
+	Hs
		276171 PSD10_HUMAN (1-110): 7.59e-30: 110: 24.32		MP2K1_HUMAN (49-344): 5.25e-65: 212: 36.69
+	Hs
		790761 CDN2A_HUMAN (3-140): 5.49e-22: 88.2: 39.57		MP2K5_HUMAN (56-324): 7.89e-66: 216: 45.09
+	Hs
		790753 CDN2A_HUMAN (3-140): 5.49e-22: 88.2: 39.57		MP2K1_HUMAN (49-344): 5.25e-65: 212: 36.69
+	Hs
		790928 CDN2B_HUMAN (9-122): 1.23e-20: 84: 45.22		MP2K5_HUMAN (56-324): 7.89e-66: 216: 45.09