HitPredict

Interactor 1: CDN2C (P42773)
Cyclin-dependent kinase 4 inhibitor C (Cyclin-dependent kinase 6 inhibitor) (p18-INK4c) (p18-INK6)
Gene: CDKN2C

Interactor 2: REL (Q04864)
Proto-oncogene c-Rel
Gene: REL

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.77	1.00	0.881

Property	Details
Experiments	25416956, 25910212, 31515488
Identification Methods	two hybrid, two hybrid prey pooling approach, two hybrid array, two hybrid bait and prey pooling approach, validated two hybrid
Interaction Type	direct interaction, physical association

Property	Details
Interacting Pfam domains	Ank_2~RHD_dimer
Common GO terms	GO:0005634 - nucleus GO:0005829 - cytosol
Homologous interactions	9

Homologous interactions

Color coding for hit scores

	1 168 Hs			1 619
+	Hs
		877473 CDN2D_HUMAN (6-159): 4e-48: 155: 45.81		REL_HUMAN (1-619): 0: 692: 100.00
+	Hs
		981733 TANC2_HUMAN (17-164): 6.3e-27: 107: 22.50		REL_HUMAN (1-619): 0: 692: 100.00
+	Hs
		964519 EHMT2_HUMAN (3-143): 9.16e-45: 158: 34.27		RELB_HUMAN (2-479): 1.52e-143: 430: 35.04
+	Hs
		276172 PSD10_HUMAN (1-110): 7.59e-30: 110: 24.32		TF65_HUMAN (2-576): 4.74e-158: 466: 37.89
+	Hs
		276140 PSD10_HUMAN (1-110): 7.59e-30: 110: 24.32		NFKB1_HUMAN (1-375): 2e-145: 447: 37.47
+	Hs
		790754 CDN2A_HUMAN (3-140): 5.49e-22: 88.2: 39.57		TF65_HUMAN (2-576): 4.74e-158: 466: 37.89
+	Hs
		978897 EHMT1_HUMAN (8-84): 7.2e-16: 76.1: 20.51		TF65_HUMAN (2-576): 4.74e-158: 466: 37.89
+	Mm
		638454 ANR42_MOUSE (12-158): 6.11e-14: 70.1: 31.79		NFKB1_MOUSE (1-414): 1.82e-152: 465: 33.56
+	Hs
		587628 ANKH1_HUMAN (74-166): 7.6e-18: 81.5: 22.58		NFKB1_HUMAN (1-375): 2e-145: 447: 37.47