HitPredict

Interactor 1: CDN2C (P42773)
Cyclin-dependent kinase 4 inhibitor C (Cyclin-dependent kinase 6 inhibitor) (p18-INK4c) (p18-INK6)
Gene: CDKN2C

Interactor 2: EZH2 (Q15910)
Histone-lysine N-methyltransferase EZH2 (EC 2.1.1.356) (ENX-1) (Enhancer of zeste homolog 2) (Lysine N-methyltransferase 6)
Gene: EZH2

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.47	0.60	0.536

Property	Details
Experiments	26496610
Identification Methods	affinity chromatography technology, anti tag coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005634 - nucleus
Homologous interactions	18

Homologous interactions

Color coding for hit scores

	1 168 Hs			1 746
+	Hs
		1080244 EHMT2_HUMAN (3-143): 9.16e-45: 158: 34.27		EZH2_HUMAN (1-746): 0: 862: 100.00
+	Mm
		1142301 EHMT2_MOUSE (3-143): 2.37e-44: 157: 34.27		EZH2_MOUSE (1-746): 0: 860: 98.39
+	Hs
		1080167 CSKI1_HUMAN (1-159): 2.96e-30: 117: 15.25		EZH2_HUMAN (1-746): 0: 862: 100.00
+	Hs
		790790 CDN2A_HUMAN (3-140): 5.49e-22: 88.2: 39.57		EZH2_HUMAN (1-746): 0: 862: 100.00
+	Hs
		1080355 EHMT1_HUMAN (8-84): 7.2e-16: 76.1: 20.51		EZH2_HUMAN (1-746): 0: 862: 100.00
+	Mm
		1125426 EHMT1_MOUSE (8-84): 1.14e-15: 75.3: 20.51		EZH2_MOUSE (1-746): 0: 860: 98.39
+	Mm
		936656 EHMT2_MOUSE (3-143): 2.37e-44: 157: 34.27		EZH1_MOUSE (15-745): 0: 755: 63.61
+	Mm
		936645 EHMT1_MOUSE (8-84): 1.14e-15: 75.3: 20.51		EZH1_MOUSE (15-745): 0: 755: 63.61
+	Mm
		1125434 EHMT2_MOUSE (3-143): 2.37e-44: 157: 34.27		EHMT1_MOUSE (445-733): 5.48e-71: 254: 25.16
+	Hs
		1296421 EHMT2_HUMAN (3-143): 9.16e-45: 158: 34.27		EHMT1_HUMAN (441-732): 1.73e-70: 253: 24.27
+	Hs
		1296396 EHMT2_HUMAN (3-143): 9.16e-45: 158: 34.27		EHMT2_HUMAN (467-732): 1.91e-68: 247: 24.21
+	Hs
		1296419 EHMT2_HUMAN (3-143): 9.16e-45: 158: 34.27		SUV92_HUMAN (447-734): 5.41e-74: 247: 24.10
+	Mm
		1378270 EHMT2_MOUSE (3-143): 2.37e-44: 157: 34.27		EHMT2_MOUSE (467-732): 2.28e-68: 247: 24.56
+	Hs
		203766 EHMT2_HUMAN (3-143): 9.16e-45: 158: 34.27		SUV91_HUMAN (354-731): 2.25e-71: 240: 19.90
+	Hs
		790870 CDN2A_HUMAN (3-140): 5.49e-22: 88.2: 39.57		NSD3_HUMAN (275-729): 9.41e-70: 251: 14.42
+	Hs
		1334130 EHMT1_HUMAN (8-84): 7.2e-16: 76.1: 20.51		EHMT1_HUMAN (441-732): 1.73e-70: 253: 24.27
+	Hs
		1331975 EHMT1_HUMAN (8-84): 7.2e-16: 76.1: 20.51		SUV92_HUMAN (447-734): 5.41e-74: 247: 24.10
+	Hs
		203794 EHMT1_HUMAN (8-84): 7.2e-16: 76.1: 20.51		SUV91_HUMAN (354-731): 2.25e-71: 240: 19.90