Interactor 1: SYUA (P37840)
Alpha-synuclein (Non-A beta component of AD amyloid) (Non-A4 component of amyloid precursor) (NACP)
Gene: SNCA

Interactor 2: SYUA (P37840)
Alpha-synuclein (Non-A beta component of AD amyloid) (Non-A4 component of amyloid precursor) (NACP)
Gene: SNCA

Species: Homo sapiens

Source: mint

Category: Small-scale

Confidence: High

Method score Annotation score Interaction score
0.99 1.00 0.996

The method score is based on:

Property Details
Experiments 25484190, 25617759, 27341336, 25555914, 25058424, 31980649, 31270237, 32430178, 33444530, 34408321, 36634849, 37242709, 39079530, 18221373, 21358815, 19651786, 20849899, 11502187, 18179253, 18505736 and 22 others

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Identification Methods pull down, biochemical, affinity chromatography technology, protein complementation assay, proximity labelling technology, two hybrid, fluorescent resonance energy transfer, bimolecular fluorescence complementation, comigration in sds page, electron microscopy and 23 others

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Interaction Type direct interaction, association, physical association

The annotation score is based on:

Property Details
Interacting Pfam domains Synuclein~Synuclein
Common GO terms GO:0000122 - negative regulation of transcription by RNA polymerase II
GO:0000149 - SNARE binding
GO:0000287 - magnesium ion binding
GO:0000976 - transcription cis-regulatory region binding
GO:0001774 - microglial cell activation
and 121 others

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Homologous interactions 3

Homologous interactions

Color coding for hit scores

1 140
Hs

1 140
+ Hs
+ Hs
+ Hs

Service provided by Combinatics, Japan

Last updated: 11Aug2025