HitPredict

Interactor 1: PFS2 (P42841)
Polyadenylation factor subunit 2
Gene: PFS2

Interactor 2: CFT1 (Q06632)
Protein CFT1 (Cleavage factor two protein 1)
Gene: CFT1

Species: Saccharomyces cerevisiae S288C

Source: mint

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.93	1.00	0.968

Property	Details
Experiments	10619842, 11713271, 11805837, 11805826, 16554755, 16429126, 37968396, 12453421
Identification Methods	affinity chromatography technology, tandem affinity purification, anti tag coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	CPSF_A~WD40
Common GO terms	GO:0005634 - nucleus GO:0005847 - mRNA cleavage and polyadenylation specificity factor complex GO:0030846 - termination of RNA polymerase II transcription, poly(A)-coupled
Homologous interactions	19

Homologous interactions

Color coding for hit scores

	1 465 Sc			1 1357
+	Hs
		1073192 FBW1A_HUMAN (23-391): 6.58e-87: 279: 20.05		SF3B3_HUMAN (1-1349): 0: 949: 12.00
+	Hs
		1082460 FBW1A_HUMAN (23-391): 6.58e-87: 279: 20.05		DDB1_HUMAN (4-1346): 0: 918: 14.25
+	Hs
		1073094 FBXW7_HUMAN (162-460): 3.24e-68: 232: 18.63		SF3B3_HUMAN (1-1349): 0: 949: 12.00
+	Hs
		1073168 NLE1_HUMAN (168-460): 1.4e-68: 228: 14.78		SF3B3_HUMAN (1-1349): 0: 949: 12.00
+	Sp
		251795 PFS2_SCHPO (15-463): 3.07e-95: 298: 34.80		CFT1_SCHPO (13-1350): 0: 868: 23.47
+	At
		1154740 FY_ARATH (1-246): 1.24e-55: 197: 15.26		DDB1A_ARATH (1-1346): 0: 932: 14.10
+	At
		221826 FY_ARATH (1-246): 1.24e-55: 197: 15.26		DDB1B_ARATH (1-1346): 0: 920: 14.54
+	Hs
		1014197 WDR33_HUMAN (7-453): 3.28e-97: 320: 32.89		CPSF1_HUMAN (2-1347): 0: 791: 17.37
+	Hs
		245605 TBL1X_HUMAN (3-250): 1.56e-54: 193: 14.43		DDB1_HUMAN (4-1346): 0: 918: 14.25
+	At
		1154738 FY_ARATH (1-246): 1.24e-55: 197: 15.26		CPSF1_ARATH (2-1347): 0: 894: 15.45
+	Hs
		1082374 TBL1R_HUMAN (214-460): 5.26e-37: 143: 13.46		DDB1_HUMAN (4-1346): 0: 918: 14.25
+	Hs
		921580 GBB2_HUMAN (193-448): 1.18e-32: 128: 17.69		DDB1_HUMAN (4-1346): 0: 918: 14.25
+	Hs
		1014208 NLE1_HUMAN (168-460): 1.4e-68: 228: 14.78		CPSF1_HUMAN (2-1347): 0: 791: 17.37
+	Hs
		903254 WDR5_HUMAN (344-460): 7.26e-19: 89.1: 12.30		DDB1_HUMAN (4-1346): 0: 918: 14.25
+	Hs
		1082327 SNR40_HUMAN (335-461): 1.7e-18: 88.3: 11.28		DDB1_HUMAN (4-1346): 0: 918: 14.25
+	Hs
		1082206 SMU1_HUMAN (65-377): 4.02e-17: 85.5: 21.18		DDB1_HUMAN (4-1346): 0: 918: 14.25
+	Hs
		1082263 WDR5B_HUMAN (333-460): 3.08e-17: 84.5: 14.29		DDB1_HUMAN (4-1346): 0: 918: 14.25
+	Hs
		560882 GBB3_HUMAN (295-450): 4.79e-09: 59.9: 11.80		DDB1_HUMAN (4-1346): 0: 918: 14.25
+	Hs
		197009 PRP4_HUMAN (205-464): 1.43e-47: 173: 14.29		CPSF1_HUMAN (2-1347): 0: 791: 17.37