HitPredict

Interactor 1: HD (P42858)
Huntingtin (Huntington disease protein) (HD protein) [Cleaved into: Huntingtin, myristoylated N-terminal fragment]
Gene: HTT

Interactor 2: ACTG (P63261)
Actin, cytoplasmic 2 (EC 3.6.4.-) (Gamma-actin) [Cleaved into: Actin, cytoplasmic 2, N-terminally processed]
Gene: ACTG1

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.64	0.60	0.621

Property	Details
Experiments	25959826, 32814053
Identification Methods	affinity chromatography technology, anti tag coimmunoprecipitation, two hybrid array, two hybrid pooling approach, validated two hybrid
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005522 - profilin binding GO:0005634 - nucleus GO:0005737 - cytoplasm GO:0005829 - cytosol GO:0030424 - axon
Homologous interactions	4

Homologous interactions

Color coding for hit scores

	1 3142 Hs			1 375
+	Hs
		791629 HD_HUMAN (1-3142): 0: 5724: 100.00		ACTBL_HUMAN (2-375): 0: 734: 91.44
+	Hs
		791436 HD_HUMAN (1-3142): 0: 5724: 100.00		ACTB_HUMAN (1-375): 0: 604: 98.93
+	Hs
		791474 HD_HUMAN (1-3142): 0: 5724: 100.00		ACTS_HUMAN (2-375): 0: 594: 93.85
+	Mm
		102909 G3X9H5_MOUSE (81-3142): 0: 5479: 91.19		ACTB_MOUSE (1-375): 0: 604: 98.93