Interactor 1: HD (P42858)
Huntingtin (Huntington disease protein) (HD protein) [Cleaved into: Huntingtin, myristoylated N-terminal fragment]
Gene: HTT

Interactor 2: BECN1 (Q14457)
Beclin-1 (Coiled-coil myosin-like BCL2-interacting protein) (Protein GT197) [Cleaved into: Beclin-1-C 35 kDa; Beclin-1-C 37 kDa]
Gene: BECN1

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score Annotation score Interaction score
0.64 0.55 0.594

The method score is based on:

Property Details
Experiments 28445460, 32814053
Identification Methods affinity chromatography technology, two hybrid array, two hybrid pooling approach, validated two hybrid, anti bait coimmunoprecipitation
Interaction Type physical association, association

The annotation score is based on:

Property Details
Interacting Pfam domains -
Common GO terms GO:0005737 - cytoplasm
GO:0005776 - autophagosome
GO:0005783 - endoplasmic reticulum
GO:0005829 - cytosol
GO:0006915 - apoptotic process
and 1 others

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Homologous interactions 0

Service provided by Combinatics, Japan

Last updated: 15 Jul 2024