HitPredict

Interactor 1: GDF5 (P43026)
Growth/differentiation factor 5 (GDF-5) (Bone morphogenetic protein 14) (BMP-14) (Cartilage-derived morphogenetic protein 1) (CDMP-1) (Lipopolysaccharide-associated protein 4) (LAP-4) (LPS-associated protein 4) (Radotermin)
Gene: GDF5

Interactor 2: BMPR2 (Q13873)
Bone morphogenetic protein receptor type-2 (BMP type-2 receptor) (BMPR-2) (EC 2.7.11.30) (Bone morphogenetic protein receptor type II) (BMP type II receptor) (BMPR-II)
Gene: BMPR2

Species: Homo sapiens

Source: mint

Category: Small-scale

Confidence: High

Method score Annotation score Interaction score
0.70 1.00 0.840

The method score is based on:

Property Details
Experiments 9525338, 18342887, 19229295
Identification Methods pull down, surface plasmon resonance
Interaction Type direct interaction, physical association

The annotation score is based on:

Property Details
Interacting Pfam domains Activin_recp~TGF_beta
Common GO terms GO:0005615 - extracellular space
GO:0005886 - plasma membrane
GO:0030509 - BMP signaling pathway
GO:0036122 - BMP binding
GO:0060391 - positive regulation of SMAD protein signal transduction
Homologous interactions 20

Homologous interactions (Top 20)

Color coding for hit scores

1 501
Hs

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Service provided by Combinatics, Japan

Last updated: 15 Jul 2024