HitPredict

Interactor 1: LIS1 (P43034)
Platelet-activating factor acetylhydrolase IB subunit beta (Lissencephaly-1 protein) (LIS-1) (PAF acetylhydrolase 45 kDa subunit) (PAF-AH 45 kDa subunit) (PAF-AH alpha) (PAFAH alpha)
Gene: PAFAH1B1

Interactor 2: DC1I2 (Q13409)
Cytoplasmic dynein 1 intermediate chain 2 (Cytoplasmic dynein intermediate chain 2) (Dynein intermediate chain 2, cytosolic) (DH IC-2)
Gene: DYNC1I2

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.74	1.00	0.861

Property	Details
Experiments	34079125, 27173435, 35271311
Identification Methods	proximity labelling technology, affinity chromatography technology, tandem affinity purification, anti tag coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	WD40~WD40
Common GO terms	GO:0005813 - centrosome GO:0005829 - cytosol
Homologous interactions	16

Homologous interactions

Color coding for hit scores

	1 410 Hs			1 638
+	Hs
		148046 LIS1_HUMAN (1-410): 7.96e-137: 399: 100.00		DC1I1_HUMAN (1-638): 2.67e-129: 396: 75.04
+	Dm
		1096834 LIS1_DROME (1-410): 6.04e-124: 366: 69.83		DYIN_DROME (6-627): 1.06e-105: 336: 46.39
+	Hs
		792949 LIS1_HUMAN (1-410): 7.96e-137: 399: 100.00		WDR5_HUMAN (112-459): 1.1e-36: 141: 10.11
+	Hs
		792935 LIS1_HUMAN (1-410): 7.96e-137: 399: 100.00		LIS1_HUMAN (472-631): 9.12e-32: 129: 16.88
+	Mm
		925836 LIS1_MOUSE (1-410): 7.14e-137: 399: 99.76		LIS1_MOUSE (472-631): 7.91e-32: 129: 16.88
+	Dm
		1358859 FBXW7_DROME (50-403): 2.3e-74: 254: 27.52		WDS_DROME (368-626): 4.13e-62: 211: 16.60
+	Hs
		1309163 TBL1Y_HUMAN (88-410): 6.01e-80: 257: 23.99		TBL1R_HUMAN (317-624): 4.89e-57: 202: 13.11
+	Ce
		954090 LIS1_CAEEL (1-410): 1.64e-115: 344: 56.93		LIN53_CAEEL (429-613): 2.09e-26: 114: 16.50
+	Dm
		1358845 WDS_DROME (19-327): 1.37e-70: 228: 25.32		WDS_DROME (368-626): 4.13e-62: 211: 16.60
+	Hs
		903349 WDR5_HUMAN (4-323): 1.79e-70: 226: 25.38		WDR5B_HUMAN (367-626): 3.82e-61: 208: 16.15
+	Hs
		245630 TBL1Y_HUMAN (88-410): 6.01e-80: 257: 23.99		TBL1X_HUMAN (364-623): 2.38e-45: 171: 15.30
+	Sp
		999842 TUP12_SCHPO (183-410): 4.31e-56: 196: 26.07		TUP11_SCHPO (365-624): 8.77e-49: 182: 14.29
+	Hs
		903551 WDR5_HUMAN (4-323): 1.79e-70: 226: 25.38		NLE1_HUMAN (466-625): 5.77e-36: 143: 14.55
+	Hs
		245633 TBL1R_HUMAN (22-265): 2.5e-57: 197: 20.08		TBL1X_HUMAN (364-623): 2.38e-45: 171: 15.30
+	Hs
		903077 WDR5_HUMAN (4-323): 1.79e-70: 226: 25.38		WDR5_HUMAN (112-459): 1.1e-36: 141: 10.11
+	Hs
		245546 TBL1X_HUMAN (22-265): 1.75e-55: 194: 19.69		TBL1X_HUMAN (364-623): 2.38e-45: 171: 15.30