HitPredict

Interactor 1: LIS1 (P43034)
Platelet-activating factor acetylhydrolase IB subunit beta (Lissencephaly-1 protein) (LIS-1) (PAF acetylhydrolase 45 kDa subunit) (PAF-AH 45 kDa subunit) (PAF-AH alpha) (PAFAH alpha)
Gene: PAFAH1B1

Interactor 2: KTNB1 (Q9BVA0)
Katanin p80 WD40 repeat-containing subunit B1 (Katanin p80 subunit B1) (p80 katanin)
Gene: KATNB1

Species: Homo sapiens

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.52	1.00	0.724

Property	Details
Experiments	16203747
Identification Methods	pull down, affinity chromatography technology
Interaction Type	direct interaction, physical association

Property	Details
Interacting Pfam domains	WD40~WD40
Common GO terms	GO:0005813 - centrosome GO:0005829 - cytosol GO:0008017 - microtubule binding GO:0043025 - neuronal cell body GO:0046982 - protein heterodimerization activity and 1 others more... GO:0070840 - dynein complex binding
Homologous interactions	18

Homologous interactions

Color coding for hit scores

	1 410 Hs			1 655
+	Hs
		792967 LIS1_HUMAN (1-410): 7.96e-137: 399: 100.00		RACK1_HUMAN (92-302): 3.5e-46: 167: 25.23
+	Hs
		792935 LIS1_HUMAN (1-410): 7.96e-137: 399: 100.00		LIS1_HUMAN (227-420): 5.51e-27: 115: 14.29
+	Mm
		925836 LIS1_MOUSE (1-410): 7.14e-137: 399: 99.76		LIS1_MOUSE (227-420): 5.01e-27: 115: 14.29
+	Hs
		209416 WDR5_HUMAN (4-323): 1.79e-70: 226: 25.38		PLRG1_HUMAN (11-323): 1.18e-86: 282: 24.52
+	Hs
		196984 WDR5_HUMAN (4-323): 1.79e-70: 226: 25.38		PRP4_HUMAN (4-301): 2.04e-83: 273: 24.38
+	Hs
		903418 WDR5_HUMAN (4-323): 1.79e-70: 226: 25.38		FBXW7_HUMAN (48-344): 6.46e-76: 258: 22.52
+	Hs
		792949 LIS1_HUMAN (1-410): 7.96e-137: 399: 100.00		WDR5_HUMAN (267-467): 4.91e-13: 72.8: 8.33
+	Hs
		903109 WDR5_HUMAN (4-323): 1.79e-70: 226: 25.38		RACK1_HUMAN (92-302): 3.5e-46: 167: 25.23
+	Hs
		903551 WDR5_HUMAN (4-323): 1.79e-70: 226: 25.38		NLE1_HUMAN (180-470): 2.03e-43: 164: 15.39
+	Hs
		863397 WDR5_HUMAN (4-323): 1.79e-70: 226: 25.38		COPA_HUMAN (1-241): 6.51e-37: 150: 18.25
+	Sc
		630844 NLE1_YEAST (17-261): 3.06e-51: 181: 20.21		NLE1_YEAST (143-470): 3.6e-50: 184: 14.45
+	Hs
		903428 WDR5_HUMAN (4-323): 1.79e-70: 226: 25.38		SNR40_HUMAN (181-384): 3.05e-30: 124: 17.62
+	Hs
		921518 GBB2_HUMAN (166-410): 8.15e-51: 175: 20.48		RACK1_HUMAN (92-302): 3.5e-46: 167: 25.23
+	Hs
		921751 GBB2_HUMAN (166-410): 8.15e-51: 175: 20.48		NLE1_HUMAN (180-470): 2.03e-43: 164: 15.39
+	Dm
		1358859 FBXW7_DROME (50-403): 2.3e-74: 254: 27.52		WDS_DROME (261-467): 4.52e-13: 73.1: 7.62
+	Dm
		1358845 WDS_DROME (19-327): 1.37e-70: 228: 25.32		WDS_DROME (261-467): 4.52e-13: 73.1: 7.62
+	Hs
		903077 WDR5_HUMAN (4-323): 1.79e-70: 226: 25.38		WDR5_HUMAN (267-467): 4.91e-13: 72.8: 8.33
+	Hs
		903349 WDR5_HUMAN (4-323): 1.79e-70: 226: 25.38		WDR5B_HUMAN (261-467): 3.81e-12: 70.1: 7.66