HitPredict

Interactor 1: MUC18 (P43121)
Cell surface glycoprotein MUC18 (Cell surface glycoprotein P1H12) (Melanoma cell adhesion molecule) (Melanoma-associated antigen A32) (Melanoma-associated antigen MUC18) (S-endo 1 endothelial-associated antigen) (CD antigen CD146)
Gene: MCAM

Interactor 2: RHOB (P62745)
Rho-related GTP-binding protein RhoB (Rho cDNA clone 6) (h6)
Gene: RHOB

Species: Homo sapiens

Source: biogrid

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.56	1.00	0.754

Property	Details
Experiments	34079125, 31871319
Identification Methods	proximity labelling technology, affinity chromatography technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	Ras~V-set
Common GO terms	GO:0001525 - angiogenesis GO:0005886 - plasma membrane GO:0005925 - focal adhesion GO:0007155 - cell adhesion
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 646 Hs			1 196
+	Hs
		793262 MUC18_HUMAN (1-646): 3.41e-136: 414: 100.00		RAC1_HUMAN (1-196): 2.37e-79: 236: 55.10
+	Hs
		793252 MUC18_HUMAN (1-646): 3.41e-136: 414: 100.00		RHOA_HUMAN (1-196): 7.19e-78: 232: 83.67
+	Hs
		545250 MUC18_HUMAN (1-646): 3.41e-136: 414: 100.00		RAC2_HUMAN (1-196): 7.63e-77: 230: 53.57
+	Hs
		436192 MUC18_HUMAN (1-646): 3.41e-136: 414: 100.00		RHOC_HUMAN (1-196): 8.84e-76: 227: 83.16
+	Hs
		793271 MUC18_HUMAN (1-646): 3.41e-136: 414: 100.00		RHOG_HUMAN (1-196): 8.84e-76: 227: 51.53
+	Hs
		793246 MUC18_HUMAN (1-646): 3.41e-136: 414: 100.00		RAC3_HUMAN (1-179): 1.15e-74: 224: 57.54
+	Hs
		793248 MUC18_HUMAN (1-646): 3.41e-136: 414: 100.00		CDC42_HUMAN (1-196): 1.35e-74: 224: 49.49
+	Hs
		564444 MUC18_HUMAN (1-646): 3.41e-136: 414: 100.00		RHOQ_HUMAN (2-195): 6.71e-68: 207: 51.74
+	Hs
		120335 MUC18_HUMAN (1-646): 3.41e-136: 414: 100.00		RHOD_HUMAN (7-182): 3.37e-66: 203: 53.98
+	Hs
		915989 ROBO2_HUMAN (1-646): 1.16e-96: 325: 14.69		RHOB_HUMAN (1-196): 7.52e-78: 232: 100.00
+	Hs
		915663 CD166_HUMAN (13-607): 2.71e-98: 314: 22.33		RHOB_HUMAN (1-196): 7.52e-78: 232: 100.00
+	Hs
		892359 CD166_HUMAN (13-607): 2.71e-98: 314: 22.33		RAC3_HUMAN (1-179): 1.15e-74: 224: 57.54
+	Hs
		530163 NCAM1_HUMAN (11-644): 1.38e-81: 277: 15.63		RHOB_HUMAN (1-196): 7.52e-78: 232: 100.00
+	Hs
		894276 PXDN_HUMAN (183-555): 5.6e-61: 222: 20.77		CDC42_HUMAN (1-196): 1.35e-74: 224: 49.49
+	Hs
		545561 KIRR1_HUMAN (240-644): 1.88e-28: 123: 15.77		RAC2_HUMAN (1-196): 7.63e-77: 230: 53.57
+	Hs
		436458 KIRR1_HUMAN (240-644): 1.88e-28: 123: 15.77		RHOC_HUMAN (1-196): 8.84e-76: 227: 83.16
+	Hs
		892541 KIRR1_HUMAN (240-644): 1.88e-28: 123: 15.77		RAC3_HUMAN (1-179): 1.15e-74: 224: 57.54
+	Hs
		894314 KIRR1_HUMAN (240-644): 1.88e-28: 123: 15.77		CDC42_HUMAN (1-196): 1.35e-74: 224: 49.49
+	Hs
		564645 KIRR1_HUMAN (240-644): 1.88e-28: 123: 15.77		RHOQ_HUMAN (2-195): 6.71e-68: 207: 51.74
+	Hs
		120585 KIRR1_HUMAN (240-644): 1.88e-28: 123: 15.77		RHOD_HUMAN (7-182): 3.37e-66: 203: 53.98