HitPredict

Interactor 1: MUC18 (P43121)
Cell surface glycoprotein MUC18 (Cell surface glycoprotein P1H12) (Melanoma cell adhesion molecule) (Melanoma-associated antigen A32) (Melanoma-associated antigen MUC18) (S-endo 1 endothelial-associated antigen) (CD antigen CD146)
Gene: MCAM

Interactor 2: CXAR (P78310)
Coxsackievirus and adenovirus receptor (CAR) (hCAR) (CVB3-binding protein) (Coxsackievirus B-adenovirus receptor) (HCVADR)
Gene: CXADR

Species: Homo sapiens

Source: biogrid

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.38	1.00	0.618

Property	Details
Experiments	38117590
Identification Methods	proximity labelling technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	C2-set_2~Ig_3, C2-set_2~V-set, Ig_3~Ig_3, Ig_3~V-set, V-set~V-set
Common GO terms	GO:0005576 - extracellular region GO:0005615 - extracellular space GO:0005886 - plasma membrane
Homologous interactions	19

Homologous interactions

Color coding for hit scores

	1 646 Hs			1 365
+	Hs
		793449 MUC18_HUMAN (1-646): 3.41e-136: 414: 100.00		JAM3_HUMAN (18-296): 2.7e-46: 162: 18.79
+	Hs
		793551 MUC18_HUMAN (1-646): 3.41e-136: 414: 100.00		ROBO1_HUMAN (11-345): 1.8e-35: 139: 14.00
+	Hs
		311052 MUC18_HUMAN (1-646): 3.41e-136: 414: 100.00		MPZL1_HUMAN (17-154): 1.8e-37: 137: 30.44
+	Hs
		1336269 ROBO2_HUMAN (1-646): 1.16e-96: 325: 14.69		ROBO2_HUMAN (1-364): 3.87e-45: 167: 13.58
+	Hs
		1336275 ROBO2_HUMAN (1-646): 1.16e-96: 325: 14.69		ROBO1_HUMAN (11-345): 1.8e-35: 139: 14.00
+	Mm
		956920 PTK7_MOUSE (141-613): 9.65e-54: 201: 15.07		CXAR_MOUSE (1-365): 2.86e-81: 254: 89.86
+	Hs
		530171 NCAM1_HUMAN (11-644): 1.38e-81: 277: 15.63		OPCM_HUMAN (1-311): 1.47e-51: 176: 17.45
+	Ce
		103933 SAX3_CAEEL (6-637): 7.59e-95: 319: 14.96		SAX3_CAEEL (11-341): 5.51e-33: 132: 12.54
+	Hs
		940526 KIRR1_HUMAN (240-644): 1.88e-28: 123: 15.77		CXAR_HUMAN (1-365): 5.66e-82: 256: 100.00
+	Hs
		1031176 PTK7_HUMAN (17-627): 1.64e-70: 249: 12.68		BTNL2_HUMAN (13-206): 1.77e-18: 88.4: 16.92
+	Dm
		219801 O44924_DROME (337-636): 3.76e-37: 151: 12.35		O44924_DROME (10-361): 2.41e-46: 171: 13.86
+	Mm
		1149039 CNTN4_MOUSE (20-612): 2.95e-44: 172: 15.30		CNTN4_MOUSE (3-313): 2.04e-24: 106: 14.62
+	Hs
		970117 CNTN2_HUMAN (266-635): 1.01e-44: 173: 13.04		NRCAM_HUMAN (1-365): 3.3e-22: 100: 11.03
+	Rn
		222935 ROBO1_RAT (17-382): 3.16e-21: 101: 11.66		DCC_RAT (1-365): 1.46e-37: 145: 12.88
+	Hs
		1378225 ROBO1_HUMAN (17-271): 4.39e-21: 100: 14.29		ROBO1_HUMAN (11-345): 1.8e-35: 139: 14.00
+	Dm
		1372240 Q9VQ08_DROME (378-643): 1.42e-22: 105: 13.72		Q9VQ08_DROME (11-335): 1.41e-23: 104: 10.54
+	Dm
		1325660 Q9GPP6_DROME (429-643): 1.26e-21: 102: 12.83		Q9GPP6_DROME (12-334): 2.54e-21: 97.7: 11.54
+	Dm
		1372236 Q9VPZ7_DROME (429-643): 1.17e-21: 102: 12.83		Q9VPZ7_DROME (12-334): 2.45e-21: 97.7: 11.54
+	Dm
		1281064 Q9VQW7_DROME (25-345): 8.83e-21: 99.6: 16.42		TUTL_DROME (139-365): 2.86e-17: 85.7: 10.49