Interactor 1: DCC (P43146)
Netrin receptor DCC (Colorectal cancer suppressor) (Immunoglobulin superfamily DCC subclass member 1) (Tumor suppressor protein DCC)
Gene: DCC

Interactor 2: FAK1 (Q05397)
Focal adhesion kinase 1 (FADK 1) (EC 2.7.10.2) (Focal adhesion kinase-related nonkinase) (FRNK) (Protein phosphatase 1 regulatory subunit 71) (PPP1R71) (Protein-tyrosine kinase 2) (p125FAK) (pp125FAK)
Gene: PTK2

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score Annotation score Interaction score
0.76 1.00 0.874

The method score is based on:

Property Details
Experiments 15494733, 28701345, 20434207
Identification Methods affinity chromatography technology, two hybrid, pull down, anti bait coimmunoprecipitation
Interaction Type physical association, direct interaction, association

The annotation score is based on:

Property Details
Interacting Pfam domains PK_Tyr_Ser-Thr~fn3, Focal_AT~Neogenin_C
Common GO terms GO:0005829 - cytosol
GO:0005886 - plasma membrane
GO:0007411 - axon guidance
Homologous interactions 15

Homologous interactions

Color coding for hit scores

1 1447
Hs

1 1052
+ Hs
+ Mm
+ Dm
+ Hs
+ Hs
+ Hs
+ Mm
+ Hs
+ Hs
+ Hs
+ Dm
+ Hs
+ Dm
+ Dm
+ Hs

Service provided by Combinatics, Japan

Last updated: 15 Jul 2024