HitPredict - High confidence protein-protein interactions

Interactor 1: MSH2 (P43247)
DNA mismatch repair protein Msh2 (MutS protein homolog 2)
Gene: MSH2

Interactor 2: MSH6 (P54276)
DNA mismatch repair protein Msh6 (G/T mismatch-binding protein) (GTBP) (GTMBP) (MutS protein homolog 6) (MutS-alpha 160 kDa subunit) (p160)
Gene: MSH6

Species: Mus musculus

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.38	1.00	0.618

Property	Details
Experiments	27886214
Identification Methods	affinity chromatography technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	MutS_I~MutS_I, MutS_I~MutS_II, MutS_I~MutS_III, MutS_I~MutS_V, MutS_II~MutS_III, MutS_II~MutS_V, MutS_III~MutS_III, MutS_III~MutS_V, MutS_V~MutS_V
Common GO terms	GO:0000287 - magnesium ion binding GO:0000400 - four-way junction DNA binding GO:0003677 - DNA binding GO:0003682 - chromatin binding GO:0003684 - damaged DNA binding and 19 others more... GO:0005524 - ATP binding GO:0005634 - nucleus GO:0005654 - nucleoplasm GO:0006298 - mismatch repair GO:0008340 - determination of adult lifespan GO:0008630 - intrinsic apoptotic signaling pathway in response to DNA damage GO:0016446 - somatic hypermutation of immunoglobulin genes GO:0016447 - somatic recombination of immunoglobulin gene segments GO:0030983 - mismatched DNA binding GO:0032137 - guanine/thymine mispair binding GO:0032142 - single guanine insertion binding GO:0032143 - single thymine insertion binding GO:0032301 - MutSalpha complex GO:0032357 - oxidized purine DNA binding GO:0032405 - MutLalpha complex binding GO:0043531 - ADP binding GO:0045190 - isotype switching GO:0045910 - negative regulation of DNA recombination GO:0140664 - ATP-dependent DNA damage sensor activity
Homologous interactions	12

Homologous interactions

Color coding for hit scores

	1	935
Mm

1	1358

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Last updated: 15 Jul 2024