HitPredict

Interactor 1: GRK6 (P43250)
G protein-coupled receptor kinase 6 (EC 2.7.11.16) (G protein-coupled receptor kinase GRK6)
Gene: GRK6

Interactor 2: FKBP5 (Q13451)
Peptidyl-prolyl cis-trans isomerase FKBP5 (PPIase FKBP5) (EC 5.2.1.8) (51 kDa FK506-binding protein) (51 kDa FKBP) (FKBP-51) (54 kDa progesterone receptor-associated immunophilin) (Androgen-regulated protein 6) (FF1 antigen) (FK506-binding protein 5) (FKBP-5) (FKBP54) (p54) (HSP90-binding immunophilin) (Rotamase)
Gene: FKBP5

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.47	1.00	0.691

Property	Details
Experiments	32707033
Identification Methods	affinity chromatography technology, pull down
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	FKBP_C~Pkinase
Common GO terms	GO:0005737 - cytoplasm GO:0016020 - membrane
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 576 Hs			1 457
+	Hs
		794379 GRK6_HUMAN (1-576): 0: 573: 100.00		FKBP4_HUMAN (1-456): 1.79e-136: 402: 54.59
+	Hs
		981051 KPCT_HUMAN (9-508): 8.49e-153: 456: 24.32		FKBP5_HUMAN (1-457): 6.63e-145: 423: 100.00
+	Hs
		1035058 AKT3_HUMAN (75-496): 8.41e-145: 428: 30.97		FKBP5_HUMAN (1-457): 6.63e-145: 423: 100.00
+	Hs
		681830 AKT1_HUMAN (75-497): 3.54e-143: 424: 30.59		FKBP5_HUMAN (1-457): 6.63e-145: 423: 100.00
+	Hs
		682173 AKT2_HUMAN (75-496): 7.73e-143: 423: 30.82		FKBP5_HUMAN (1-457): 6.63e-145: 423: 100.00
+	Hs
		969070 KPCE_HUMAN (11-507): 2.06e-147: 444: 24.09		FKBP4_HUMAN (1-456): 1.79e-136: 402: 54.59
+	Hs
		568651 KAPCA_HUMAN (144-500): 5.83e-144: 421: 28.85		FKBP5_HUMAN (1-457): 6.63e-145: 423: 100.00
+	Hs
		610723 KAPCB_HUMAN (144-500): 4.26e-143: 419: 29.69		FKBP5_HUMAN (1-457): 6.63e-145: 423: 100.00
+	Hs
		609666 KAPCG_HUMAN (144-500): 1.69e-142: 417: 26.89		FKBP5_HUMAN (1-457): 6.63e-145: 423: 100.00
+	Hs
		609664 KAPCG_HUMAN (144-500): 1.69e-142: 417: 26.89		FKBP4_HUMAN (1-456): 1.79e-136: 402: 54.59
+	Hs
		118703 GRK6_HUMAN (1-576): 0: 573: 100.00		AIP_HUMAN (144-414): 1.52e-49: 173: 16.72
+	Hs
		794384 GRK6_HUMAN (1-576): 0: 573: 100.00		FKBP8_HUMAN (25-330): 3.36e-27: 114: 19.23
+	Hs
		1035034 KS6B2_HUMAN (186-485): 2.72e-57: 201: 39.09		FKBP5_HUMAN (1-457): 6.63e-145: 423: 100.00
+	Hs
		684433 GRK4_HUMAN (1-575): 1.17e-168: 492: 65.34		STIP1_HUMAN (265-457): 3.91e-23: 104: 17.62
+	Hs
		118692 KAPCG_HUMAN (144-500): 1.69e-142: 417: 26.89		AIP_HUMAN (144-414): 1.52e-49: 173: 16.72
+	Hs
		1053096 GRK7_HUMAN (3-541): 2.39e-146: 435: 44.14		FKBP8_HUMAN (25-330): 3.36e-27: 114: 19.23
+	Hs
		568664 KAPCA_HUMAN (144-500): 5.83e-144: 421: 28.85		FKBP8_HUMAN (25-330): 3.36e-27: 114: 19.23
+	Hs
		609671 KAPCG_HUMAN (144-500): 1.69e-142: 417: 26.89		FKBP8_HUMAN (25-330): 3.36e-27: 114: 19.23
+	Rn
		193486 AKT3_RAT (75-496): 6.79e-143: 423: 30.73		STIP1_RAT (265-457): 1.25e-22: 102: 18.14
+	Hs
		609649 KAPCG_HUMAN (144-500): 1.69e-142: 417: 26.89		STIP1_HUMAN (265-457): 3.91e-23: 104: 17.62