HitPredict

Interactor 1: GRK6 (P43250)
G protein-coupled receptor kinase 6 (EC 2.7.11.16) (G protein-coupled receptor kinase GRK6)
Gene: GRK6

Interactor 2: NOLC1 (Q14978)
Nucleolar and coiled-body phosphoprotein 1 (140 kDa nucleolar phosphoprotein) (Nopp140) (Hepatitis C virus NS5A-transactivated protein 13) (HCV NS5A-transactivated protein 13) (Nucleolar 130 kDa protein) (Nucleolar phosphoprotein p130)
Gene: NOLC1

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.65	0.60	0.628

Property	Details
Experiments	28514442, 33961781
Identification Methods	affinity chromatography technology, anti tag coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005524 - ATP binding GO:0005737 - cytoplasm
Homologous interactions	10

Homologous interactions

Color coding for hit scores

	1 576 Hs			1 699
+	Hs
		714535 GRK5_HUMAN (1-563): 1.85e-175: 510: 71.76		NOLC1_HUMAN (1-699): 6.47e-68: 237: 100.00
+	Hs
		973316 KPCD_HUMAN (9-518): 2.81e-144: 434: 24.86		TOP2B_HUMAN (6-463): 1.53e-66: 241: 14.13
+	Hs
		509067 GRK7_HUMAN (3-541): 2.39e-146: 435: 44.14		TOP2A_HUMAN (6-372): 1.49e-41: 165: 14.44
+	Hs
		508957 KPCD_HUMAN (9-518): 2.81e-144: 434: 24.86		TOP2A_HUMAN (6-372): 1.49e-41: 165: 14.44
+	Hs
		714556 GRK5_HUMAN (1-563): 1.85e-175: 510: 71.76		SRRM1_HUMAN (8-680): 2.28e-09: 62.7: 9.64
+	Mm
		93785 KAPCA_MOUSE (144-500): 3.36e-143: 419: 28.57		E9QJV1_MOUSE (90-695): 3.84e-12: 71.9: 10.20
+	Hs
		408616 KPCB_HUMAN (191-498): 2.23e-57: 205: 38.07		NOLC1_HUMAN (1-699): 6.47e-68: 237: 100.00
+	Hs
		508811 KPCA_HUMAN (176-496): 1.87e-58: 208: 38.08		TOP2A_HUMAN (6-372): 1.49e-41: 165: 14.44
+	Hs
		408541 KPCB_HUMAN (191-498): 2.23e-57: 205: 38.07		TOP2A_HUMAN (6-372): 1.49e-41: 165: 14.44
+	Dm
		532264 KPC2_DROME (137-498): 3.6e-57: 205: 35.05		TRP_DROME (75-337): 1.24e-11: 70.4: 15.21