HitPredict

Interactor 1: GRK6 (P43250)
G protein-coupled receptor kinase 6 (EC 2.7.11.16) (G protein-coupled receptor kinase GRK6)
Gene: GRK6

Interactor 2: H90B4 (Q58FF6)
Putative heat shock protein HSP 90-beta 4
Gene: HSP90AB4P

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.33	1.00	0.575

Property	Details
Experiments	32707033
Identification Methods	pull down
Interaction Type	association

Property	Details
Interacting Pfam domains	HSP90~Pkinase
Common GO terms	GO:0005524 - ATP binding GO:0005886 - plasma membrane
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 576 Hs			1 505
+	Hs
		437972 GRK6_HUMAN (1-576): 0: 573: 100.00		HS90B_HUMAN (1-504): 0: 671: 69.93
+	Hs
		431631 GRK6_HUMAN (1-576): 0: 573: 100.00		HS90A_HUMAN (1-504): 0: 655: 62.96
+	Hs
		437937 GRK5_HUMAN (1-563): 1.85e-175: 510: 71.76		HS90B_HUMAN (1-504): 0: 671: 69.93
+	Hs
		431584 GRK5_HUMAN (1-563): 1.85e-175: 510: 71.76		HS90A_HUMAN (1-504): 0: 655: 62.96
+	Hs
		437932 GRK4_HUMAN (1-575): 1.17e-168: 492: 65.34		HS90B_HUMAN (1-504): 0: 671: 69.93
+	Hs
		431575 GRK4_HUMAN (1-575): 1.17e-168: 492: 65.34		HS90A_HUMAN (1-504): 0: 655: 62.96
+	Hs
		438094 KPCT_HUMAN (9-508): 8.49e-153: 456: 24.32		HS90B_HUMAN (1-504): 0: 671: 69.93
+	Hs
		438085 KPCE_HUMAN (11-507): 2.06e-147: 444: 24.09		HS90B_HUMAN (1-504): 0: 671: 69.93
+	Hs
		437909 ARBK1_HUMAN (2-541): 2.79e-147: 442: 36.59		HS90B_HUMAN (1-504): 0: 671: 69.93
+	Hs
		431762 KPCT_HUMAN (9-508): 8.49e-153: 456: 24.32		HS90A_HUMAN (1-504): 0: 655: 62.96
+	Hs
		438392 GRK7_HUMAN (3-541): 2.39e-146: 435: 44.14		HS90B_HUMAN (1-504): 0: 671: 69.93
+	Hs
		437907 KPCL_HUMAN (11-510): 1.35e-142: 429: 24.61		HS90B_HUMAN (1-504): 0: 671: 69.93
+	Hs
		431752 KPCE_HUMAN (11-507): 2.06e-147: 444: 24.09		HS90A_HUMAN (1-504): 0: 655: 62.96
+	Bt
		964601 AKT1_BOVIN (75-497): 6.77e-145: 428: 30.59		HS90B_BOVIN (1-504): 0: 670: 69.76
+	Hs
		431550 ARBK1_HUMAN (2-541): 2.79e-147: 442: 36.59		HS90A_HUMAN (1-504): 0: 655: 62.96
+	Mm
		432407 KPCD_MOUSE (9-517): 2.55e-147: 441: 24.90		HS90A_MOUSE (1-504): 0: 652: 61.81
+	Hs
		432101 GRK7_HUMAN (3-541): 2.39e-146: 435: 44.14		HS90A_HUMAN (1-504): 0: 655: 62.96
+	Hs
		431767 KPCD_HUMAN (9-518): 2.81e-144: 434: 24.86		HS90A_HUMAN (1-504): 0: 655: 62.96
+	Rn
		448409 KPCD_RAT (9-517): 4.63e-145: 435: 24.52		HS90A_RAT (1-504): 0: 654: 61.98
+	Hs
		431548 KPCL_HUMAN (11-510): 1.35e-142: 429: 24.61		HS90A_HUMAN (1-504): 0: 655: 62.96