HitPredict

Interactor 1: SMD3 (P43321)
Small nuclear ribonucleoprotein Sm D3 (Sm-D3) (snRNP core protein D3)
Gene: SMD3

Interactor 2: LSM6 (Q06406)
U6 snRNA-associated Sm-like protein LSm6
Gene: LSM6

Species: Saccharomyces cerevisiae S288C

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.62	1.00	0.789

Property	Details
Experiments	10377396, 16429126
Identification Methods	biochemical, affinity chromatography technology, tandem affinity purification
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	LSM~LSM
Common GO terms	GO:0000398 - mRNA splicing, via spliceosome GO:0003723 - RNA binding GO:0005634 - nucleus GO:0005681 - spliceosomal complex GO:0046540 - U4/U6 x U5 tri-snRNP complex and 1 others more... GO:0071001 - U4/U6 snRNP
Homologous interactions	19

Homologous interactions

Color coding for hit scores

	1 101 Sc			1 86
+	Hs
		912260 LSM4_HUMAN (6-89): 6.88e-35: 118: 35.29		LSM6_HUMAN (10-85): 1.6e-34: 114: 46.05
+	Hs
		911795 SMD3_HUMAN (3-100): 3.04e-35: 118: 42.86		RUXF_HUMAN (12-82): 9.86e-32: 107: 35.21
+	Hs
		912008 LSM4_HUMAN (6-89): 6.88e-35: 118: 35.29		RUXF_HUMAN (12-82): 9.86e-32: 107: 35.21
+	Dm
		1369699 Q9VKW8_DROME (6-92): 1.45e-34: 117: 35.23		Q9W2P5_DROME (13-85): 1.72e-31: 106: 42.47
+	Dm
		218361 SMD3_DROME (3-100): 7e-36: 120: 41.84		RUXF_DROME (12-82): 2.82e-29: 101: 35.21
+	Hs
		912257 LSM2_HUMAN (9-90): 5.65e-30: 104: 20.24		LSM6_HUMAN (10-85): 1.6e-34: 114: 46.05
+	Hs
		912217 SMD1_HUMAN (7-96): 7.75e-29: 101: 23.33		LSM6_HUMAN (10-85): 1.6e-34: 114: 46.05
+	Dm
		1374115 Q9VTW6_DROME (9-90): 1.07e-30: 105: 20.24		Q9W2P5_DROME (13-85): 1.72e-31: 106: 42.47
+	Hs
		912002 LSM2_HUMAN (9-90): 5.65e-30: 104: 20.24		RUXF_HUMAN (12-82): 9.86e-32: 107: 35.21
+	Hs
		911792 RUXF_HUMAN (7-73): 2.92e-27: 96.9: 26.87		LSM6_HUMAN (10-85): 1.6e-34: 114: 46.05
+	Hs
		912243 LSM10_HUMAN (7-100): 8.88e-27: 96.9: 20.41		LSM6_HUMAN (10-85): 1.6e-34: 114: 46.05
+	Hs
		911793 SMD1_HUMAN (7-96): 7.75e-29: 101: 23.33		RUXF_HUMAN (12-82): 9.86e-32: 107: 35.21
+	At
		1352880 RUXF_ARATH (7-86): 6.99e-29: 101: 22.22		RUXF_ARATH (12-82): 3.56e-30: 103: 32.39
+	Hs
		911921 LSM10_HUMAN (7-100): 8.88e-27: 96.9: 20.41		RUXF_HUMAN (12-82): 9.86e-32: 107: 35.21
+	Sc
		795402 SMD3_YEAST (1-101): 1.39e-34: 115: 100.00		RUXF_YEAST (12-83): 5.95e-24: 87.8: 28.77
+	Sc
		746349 LSM2_YEAST (9-90): 3.45e-24: 89.6: 17.86		LSM6_YEAST (1-86): 9.43e-30: 102: 100.00
+	Sc
		767833 LSM4_YEAST (6-101): 5.39e-23: 88.8: 23.36		LSM6_YEAST (1-86): 9.43e-30: 102: 100.00
+	Sc
		746330 LSM2_YEAST (9-90): 3.45e-24: 89.6: 17.86		RUXF_YEAST (12-83): 5.95e-24: 87.8: 28.77
+	Sc
		767814 LSM4_YEAST (6-101): 5.39e-23: 88.8: 23.36		RUXF_YEAST (12-83): 5.95e-24: 87.8: 28.77