HitPredict

Interactor 1: SMD3 (P43321)
Small nuclear ribonucleoprotein Sm D3 (Sm-D3) (snRNP core protein D3)
Gene: SMD3

Interactor 2: CLF1 (Q12309)
Pre-mRNA-splicing factor CLF1 (Crooked neck-like factor 1) (PRP19-associated complex protein 77) (Synthetic lethal with CDC40 protein 3)
Gene: CLF1

Species: Saccharomyces cerevisiae S288C

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.56	0.60	0.584

Property	Details
Experiments	12509417, 37968396
Identification Methods	affinity chromatography technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0000245 - spliceosomal complex assembly GO:0000398 - mRNA splicing, via spliceosome GO:0071004 - U2-type prespliceosome GO:0071011 - precatalytic spliceosome
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 101 Sc			1 687
+	Sc
		746365 LSM2_YEAST (9-90): 3.45e-24: 89.6: 17.86		CLF1_YEAST (1-687): 7.93e-126: 390: 100.00
+	Hs
		1318167 LSM2_HUMAN (9-90): 5.65e-30: 104: 20.24		CRNL1_HUMAN (5-685): 4.45e-115: 367: 36.61
+	Hs
		911958 RUXF_HUMAN (7-73): 2.92e-27: 96.9: 26.87		CRNL1_HUMAN (5-685): 4.45e-115: 367: 36.61
+	Sc
		795418 SMD3_YEAST (1-101): 1.39e-34: 115: 100.00		SYF1_YEAST (54-674): 1.42e-57: 211: 11.97
+	Hs
		912738 SMD3_HUMAN (3-100): 3.04e-35: 118: 42.86		SYF1_HUMAN (2-495): 4.59e-26: 116: 14.67
+	Hs
		911970 RUXF_HUMAN (7-73): 2.92e-27: 96.9: 26.87		SYF1_HUMAN (2-495): 4.59e-26: 116: 14.67
+	Sp
		1015547 SMD3_SCHPO (4-101): 1.27e-32: 110: 51.02		PRP1_SCHPO (1-392): 2.83e-20: 98.1: 13.22
+	Sp
		193907 SMD1_SCHPO (7-96): 1.57e-28: 101: 24.44		PRP1_SCHPO (1-392): 2.83e-20: 98.1: 13.22
+	Hs
		911872 RUXF_HUMAN (7-73): 2.92e-27: 96.9: 26.87		CTR9_HUMAN (9-434): 5.17e-19: 94.2: 8.39
+	Hs
		1063317 LSM4_HUMAN (6-89): 6.88e-35: 118: 35.29		SART3_HUMAN (21-387): 2.31e-11: 69.2: 15.08
+	Hs
		912638 SMD3_HUMAN (3-100): 3.04e-35: 118: 42.86		SART3_HUMAN (21-387): 2.31e-11: 69.2: 15.08
+	Hs
		300104 SMD3_HUMAN (3-100): 3.04e-35: 118: 42.86		PRP6_HUMAN (449-672): 5e-10: 64.9: 11.89
+	Hs
		300299 LSM4_HUMAN (6-89): 6.88e-35: 118: 35.29		PRP6_HUMAN (449-672): 5e-10: 64.9: 11.89
+	Sc
		586416 SMD3_YEAST (1-101): 1.39e-34: 115: 100.00		PRP6_YEAST (28-198): 6.71e-10: 64.6: 13.30
+	Hs
		1063313 LSM2_HUMAN (9-90): 5.65e-30: 104: 20.24		SART3_HUMAN (21-387): 2.31e-11: 69.2: 15.08
+	Hs
		300294 LSM2_HUMAN (9-90): 5.65e-30: 104: 20.24		PRP6_HUMAN (449-672): 5e-10: 64.9: 11.89
+	Hs
		911838 RUXF_HUMAN (7-73): 2.92e-27: 96.9: 26.87		SART3_HUMAN (21-387): 2.31e-11: 69.2: 15.08
+	Hs
		300099 RUXF_HUMAN (7-73): 2.92e-27: 96.9: 26.87		PRP6_HUMAN (449-672): 5e-10: 64.9: 11.89
+	Sc
		586396 LSM2_YEAST (9-90): 3.45e-24: 89.6: 17.86		PRP6_YEAST (28-198): 6.71e-10: 64.6: 13.30
+	Sc
		586409 LSM4_YEAST (6-101): 5.39e-23: 88.8: 23.36		PRP6_YEAST (28-198): 6.71e-10: 64.6: 13.30