HitPredict

Interactor 1: NR4A2 (P43354)
Nuclear receptor subfamily 4 group A member 2 (Immediate-early response protein NOT) (Orphan nuclear receptor NURR1) (Transcriptionally-inducible nuclear receptor)
Gene: NR4A2

Interactor 2: CDN2D (P55273)
Cyclin-dependent kinase 4 inhibitor D (p19-INK4d)
Gene: CDKN2D

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.77	0.60	0.683

Property	Details
Experiments	25416956, 32296183, unassigned1304, 31515488
Identification Methods	two hybrid, two hybrid prey pooling approach, two hybrid array, validated two hybrid
Interaction Type	direct interaction, physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005634 - nucleus GO:0005654 - nucleoplasm GO:0005737 - cytoplasm
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 598 Hs			1 166
+	Hs
		93993 F1D8N6_HUMAN (1-598): 3.82e-178: 519: 100.00		CDN2D_HUMAN (1-166): 5.02e-52: 165: 100.00
+	Hs
		611407 NR4A1_HUMAN (1-598): 1.09e-127: 389: 49.68		CDN2D_HUMAN (1-166): 5.02e-52: 165: 100.00
+	Hs
		877496 NR4A3_HUMAN (1-598): 1.93e-120: 371: 51.25		CDN2D_HUMAN (1-166): 5.02e-52: 165: 100.00
+	Hs
		487930 RARA_HUMAN (173-594): 5.71e-108: 334: 28.30		CDN2D_HUMAN (1-166): 5.02e-52: 165: 100.00
+	Hs
		370687 ESR1_HUMAN (107-592): 4.51e-111: 346: 23.23		KDIS_HUMAN (2-142): 6.12e-36: 133: 23.29
+	Hs
		370593 ESR1_HUMAN (107-592): 4.51e-111: 346: 23.23		RAI14_HUMAN (5-142): 1.32e-35: 132: 25.18
+	Hs
		1269795 ESR2_HUMAN (129-592): 1.3e-107: 335: 23.44		RAI14_HUMAN (5-142): 1.32e-35: 132: 25.18
+	Hs
		987833 ESR2_HUMAN (129-592): 1.3e-107: 335: 23.44		GABP1_HUMAN (42-164): 2.15e-34: 126: 29.84
+	Hs
		1251348 ESR2_HUMAN (129-592): 1.3e-107: 335: 23.44		GABP2_HUMAN (42-164): 9.36e-34: 124: 29.84
+	Hs
		370465 ESR1_HUMAN (107-592): 4.51e-111: 346: 23.23		EHMT1_HUMAN (2-120): 2.72e-26: 105: 20.83
+	Hs
		377204 GCR_HUMAN (2-597): 1.22e-103: 332: 18.72		DAPK1_HUMAN (35-165): 5.87e-27: 107: 23.70
+	Hs
		377694 GCR_HUMAN (2-597): 1.22e-103: 332: 18.72		EHMT1_HUMAN (2-120): 2.72e-26: 105: 20.83
+	Hs
		377700 GCR_HUMAN (2-597): 1.22e-103: 332: 18.72		TANC2_HUMAN (23-163): 2.12e-23: 97.5: 18.97
+	Hs
		487995 RARA_HUMAN (173-594): 5.71e-108: 334: 28.30		HACE1_HUMAN (2-100): 2.63e-21: 91.5: 24.00
+	Hs
		500370 RARB_HUMAN (173-594): 9.66e-108: 333: 27.36		HACE1_HUMAN (2-100): 2.63e-21: 91.5: 24.00
+	Hs
		370223 ESR1_HUMAN (107-592): 4.51e-111: 346: 23.23		EHMT2_HUMAN (2-77): 4.8e-14: 70.7: 15.60
+	Hs
		1206010 ESR2_HUMAN (129-592): 1.3e-107: 335: 23.44		MIB1_HUMAN (4-114): 1.05e-17: 80.9: 20.92
+	Hs
		377458 GCR_HUMAN (2-597): 1.22e-103: 332: 18.72		MIB1_HUMAN (4-114): 1.05e-17: 80.9: 20.92
+	Hs
		1269380 ESR2_HUMAN (129-592): 1.3e-107: 335: 23.44		EHMT2_HUMAN (2-77): 4.8e-14: 70.7: 15.60
+	Hs
		377497 GCR_HUMAN (2-597): 1.22e-103: 332: 18.72		ANR52_HUMAN (1-161): 1.16e-09: 57.8: 30.77