HitPredict

Interactor 1: MAGA3 (P43357)
Melanoma-associated antigen 3 (Antigen MZ2-D) (Cancer/testis antigen 1.3) (CT1.3) (MAGE-3 antigen)
Gene: MAGEA3

Interactor 2: MAGA6 (P43360)
Melanoma-associated antigen 6 (Cancer/testis antigen 1.6) (CT1.6) (MAGE-6 antigen) (MAGE3B antigen)
Gene: MAGEA6

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.62	1.00	0.789

Property	Details
Experiments	31267705, 33961781
Identification Methods	affinity chromatography technology, anti tag coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	MAGE~MAGE
Common GO terms	GO:0000122 - negative regulation of transcription by RNA polymerase II GO:0005634 - nucleus GO:0010507 - negative regulation of autophagy GO:0042826 - histone deacetylase binding
Homologous interactions	14

Homologous interactions

Color coding for hit scores

	1 314 Hs			1 314
+	Hs
		796255 MAGAB_HUMAN (1-314): 2.21e-154: 440: 59.62		MAGAB_HUMAN (1-314): 1.15e-153: 438: 59.62
+	Hs
		795849 MAGAB_HUMAN (1-314): 2.21e-154: 440: 59.62		MAGA6_HUMAN (1-314): 2.85e-148: 420: 100.00
+	Hs
		795716 MAGA3_HUMAN (1-314): 8.98e-156: 439: 100.00		MAGA8_HUMAN (1-313): 4.9e-147: 417: 63.29
+	Hs
		795688 MAGA3_HUMAN (1-314): 8.98e-156: 439: 100.00		MAGA2_HUMAN (1-314): 1.73e-142: 406: 83.76
+	Hs
		795805 MAGA4_HUMAN (1-304): 5.82e-150: 425: 68.85		MAGA8_HUMAN (1-313): 4.9e-147: 417: 63.29
+	Hs
		795807 MAGA4_HUMAN (1-304): 5.82e-150: 425: 68.85		MAGAA_HUMAN (1-314): 2.37e-141: 405: 48.38
+	Hs
		180537 MAGA3_HUMAN (1-314): 8.98e-156: 439: 100.00		MAGB4_HUMAN (1-314): 4e-134: 386: 39.81
+	Hs
		795806 MAGA4_HUMAN (1-304): 5.82e-150: 425: 68.85		MAGA9_HUMAN (1-314): 7.03e-135: 386: 56.78
+	Hs
		56489 MAGA4_HUMAN (1-304): 5.82e-150: 425: 68.85		MAGBG_HUMAN (1-314): 2.29e-133: 383: 41.51
+	Hs
		180538 MAGA8_HUMAN (1-313): 3.22e-147: 418: 63.29		MAGB4_HUMAN (1-314): 4e-134: 386: 39.81
+	Hs
		1297544 MAGBI_HUMAN (1-313): 1.11e-144: 412: 39.94		MAGBA_HUMAN (1-311): 3.12e-133: 384: 37.90
+	Hs
		796054 MAGAA_HUMAN (1-314): 6.43e-143: 409: 47.20		MAGA9_HUMAN (1-314): 7.03e-135: 386: 56.78
+	Hs
		796241 MAGAA_HUMAN (1-314): 6.43e-143: 409: 47.20		MAGBA_HUMAN (1-311): 3.12e-133: 384: 37.90
+	Hs
		180521 MAGB3_HUMAN (1-314): 1.54e-140: 402: 36.28		MAGA1_HUMAN (1-303): 4.46e-136: 389: 67.66