HitPredict

Interactor 1: MAGA3 (P43357)
Melanoma-associated antigen 3 (Antigen MZ2-D) (Cancer/testis antigen 1.3) (CT1.3) (MAGE-3 antigen)
Gene: MAGEA3

Interactor 2: TIF1B (Q13263)
Transcription intermediary factor 1-beta (TIF1-beta) (E3 SUMO-protein ligase TRIM28) (EC 2.3.2.27) (KRAB-associated protein 1) (KAP-1) (KRAB-interacting protein 1) (KRIP-1) (Nuclear corepressor KAP-1) (RING finger protein 96) (RING-type E3 ubiquitin transferase TIF1-beta) (Tripartite motif-containing protein 28)
Gene: TRIM28

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.81	0.60	0.701

Property	Details
Experiments	28394358, 20864041, 31267705, 21277283
Identification Methods	affinity chromatography technology, pull down, two hybrid, tandem affinity purification
Interaction Type	physical association, direct interaction

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0000122 - negative regulation of transcription by RNA polymerase II GO:0005634 - nucleus
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 314 Hs			1 835
+	Hs
		796271 MAGAB_HUMAN (1-314): 2.21e-154: 440: 59.62		TIF1B_HUMAN (18-835): 3.77e-174: 525: 100.00
+	Hs
		795861 MAGA6_HUMAN (1-314): 3.52e-149: 423: 95.86		TIF1B_HUMAN (18-835): 3.77e-174: 525: 100.00
+	Hs
		795693 MAGA2_HUMAN (1-314): 2.11e-143: 408: 84.40		TIF1B_HUMAN (18-835): 3.77e-174: 525: 100.00
+	Hs
		796068 MAGA9_HUMAN (1-314): 4.46e-136: 389: 58.36		TIF1B_HUMAN (18-835): 3.77e-174: 525: 100.00
+	Hs
		180307 MAGB2_HUMAN (1-314): 1.02e-118: 345: 36.79		TIF1B_HUMAN (18-835): 3.77e-174: 525: 100.00
+	Hs
		1029757 NSE3_HUMAN (22-313): 1.15e-109: 322: 32.42		TIF1B_HUMAN (18-835): 3.77e-174: 525: 100.00
+	Hs
		1029972 MAGC2_HUMAN (96-314): 1.3e-104: 312: 47.03		TIF1B_HUMAN (18-835): 3.77e-174: 525: 100.00
+	Hs
		1030070 MAGD1_HUMAN (27-306): 1.06e-90: 288: 29.54		TIF1B_HUMAN (18-835): 3.77e-174: 525: 100.00
+	Hs
		795928 MAGA6_HUMAN (1-314): 3.52e-149: 423: 95.86		TRIM1_HUMAN (40-589): 4.03e-64: 231: 15.36
+	Hs
		668498 MAGA2_HUMAN (1-314): 2.11e-143: 408: 84.40		PML_HUMAN (29-609): 1.21e-57: 214: 14.00
+	Hs
		170294 MAGAA_HUMAN (1-314): 6.43e-143: 409: 47.20		TIF1A_HUMAN (404-808): 1.31e-52: 200: 21.55
+	Hs
		795665 MAGA1_HUMAN (1-303): 3.01e-138: 395: 67.00		TRIM8_HUMAN (59-589): 2.74e-56: 205: 16.09
+	Hs
		796205 MAGA9_HUMAN (1-314): 4.46e-136: 389: 58.36		TRI33_HUMAN (406-826): 1.6e-54: 206: 19.32
+	Hs
		170293 MAGA9_HUMAN (1-314): 4.46e-136: 389: 58.36		TIF1A_HUMAN (404-808): 1.31e-52: 200: 21.55
+	Hs
		795671 MAGA1_HUMAN (1-303): 3.01e-138: 395: 67.00		SP14L_HUMAN (257-800): 1.89e-48: 183: 13.85
+	Hs
		180220 MAGB2_HUMAN (1-314): 1.02e-118: 345: 36.79		PML_HUMAN (29-609): 1.21e-57: 214: 14.00
+	Hs
		180438 MAGB2_HUMAN (1-314): 1.02e-118: 345: 36.79		TRI56_HUMAN (47-532): 1.21e-51: 195: 17.68
+	Hs
		669077 MAGD2_HUMAN (16-309): 1.73e-105: 322: 29.59		PML_HUMAN (29-609): 1.21e-57: 214: 14.00
+	Hs
		1318355 MAGC2_HUMAN (96-314): 1.3e-104: 312: 47.03		TRIM8_HUMAN (59-589): 2.74e-56: 205: 16.09
+	Hs
		669108 MAGD1_HUMAN (27-306): 1.06e-90: 288: 29.54		PML_HUMAN (29-609): 1.21e-57: 214: 14.00