HitPredict

Interactor 1: ZAP70 (P43403)
Tyrosine-protein kinase ZAP-70 (EC 2.7.10.2) (70 kDa zeta-chain associated protein) (Syk-related tyrosine kinase)
Gene: ZAP70

Interactor 2: GRB2 (P62993)
Growth factor receptor-bound protein 2 (Adapter protein GRB2) (Protein Ash) (SH2/SH3 adapter GRB2)
Gene: GRB2

Species: Homo sapiens

Source: biogrid

Category: Small-scale

Confidence: High

Method score Annotation score Interaction score
0.56 1.00 0.754

The method score is based on:

Property Details
Experiments 7629168, 23267066
Identification Methods affinity chromatography technology
Interaction Type physical association

The annotation score is based on:

Property Details
Interacting Pfam domains PK_Tyr_Ser-Thr~SH2, PK_Tyr_Ser-Thr~SH3_1, SH2~SH2, SH2~SH3_1
Common GO terms GO:0001784 - phosphotyrosine residue binding
GO:0005737 - cytoplasm
GO:0005829 - cytosol
GO:0005886 - plasma membrane
GO:0005911 - cell-cell junction
Homologous interactions 20

Homologous interactions (Top 20)

Color coding for hit scores

1 619
Hs

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Service provided by Combinatics, Japan

Last updated: 15 Jul 2024