HitPredict

Interactor 1: ZAP70 (P43403)
Tyrosine-protein kinase ZAP-70 (EC 2.7.10.2) (70 kDa zeta-chain associated protein) (Syk-related tyrosine kinase)
Gene: ZAP70

Interactor 2: SLAP2 (Q9H6Q3)
Src-like-adapter 2 (Modulator of antigen receptor signaling) (MARS) (Src-like adapter protein 2) (SLAP-2)
Gene: SLA2

Species: Homo sapiens

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.38	1.00	0.618

Property	Details
Experiments	11891219
Identification Methods	affinity chromatography technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	PK_Tyr_Ser-Thr~SH2, PK_Tyr_Ser-Thr~SH3_1, SH2~SH2, SH2~SH3_1
Common GO terms	GO:0001784 - phosphotyrosine residue binding GO:0005737 - cytoplasm GO:0005829 - cytosol GO:0005886 - plasma membrane GO:0042110 - T cell activation
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 619 Hs			1 261
+	Hs
		412075 ZAP70_HUMAN (1-619): 0: 641: 100.00		FYN_HUMAN (6-259): 1.62e-81: 255: 31.68
+	Hs
		411632 ZAP70_HUMAN (1-619): 0: 641: 100.00		LCK_HUMAN (2-259): 1.98e-78: 247: 30.57
+	Mm
		411920 ZAP70_MOUSE (1-619): 0: 633: 92.90		LCK_MOUSE (3-259): 8.31e-79: 248: 31.06
+	Mm
		796515 ZAP70_MOUSE (1-619): 0: 633: 92.90		SLAP2_MOUSE (1-261): 1.55e-71: 221: 76.72
+	Hs
		337385 ZAP70_HUMAN (1-619): 0: 641: 100.00		ABL1_HUMAN (2-260): 1.1e-59: 205: 23.60
+	Hs
		782752 ZAP70_HUMAN (1-619): 0: 641: 100.00		CSK_HUMAN (18-240): 5.46e-60: 198: 27.54
+	Hs
		796470 ZAP70_HUMAN (1-619): 0: 641: 100.00		SLAP1_HUMAN (13-259): 4.83e-60: 193: 38.49
+	Mm
		796504 ZAP70_MOUSE (1-619): 0: 633: 92.90		SLAP1_MOUSE (13-257): 4.05e-58: 188: 40.95
+	Hs
		412076 KSYK_HUMAN (1-600): 0: 554: 53.58		FYN_HUMAN (6-259): 1.62e-81: 255: 31.68
+	Hs
		433635 KSYK_HUMAN (1-600): 0: 554: 53.58		LYN_HUMAN (6-257): 7.42e-80: 251: 31.27
+	Hs
		454806 KSYK_HUMAN (1-600): 0: 554: 53.58		FGR_HUMAN (6-259): 4.1e-79: 249: 30.92
+	Hs
		411633 KSYK_HUMAN (1-600): 0: 554: 53.58		LCK_HUMAN (2-259): 1.98e-78: 247: 30.57
+	Hs
		522845 KSYK_HUMAN (1-600): 0: 554: 53.58		SRC_HUMAN (13-259): 9.05e-77: 243: 31.37
+	Hs
		796550 KSYK_HUMAN (1-600): 0: 554: 53.58		BTK_HUMAN (10-260): 1.44e-64: 214: 21.46
+	Hs
		796562 KSYK_HUMAN (1-600): 0: 554: 53.58		SLAP1_HUMAN (13-259): 4.83e-60: 193: 38.49
+	Hs
		796465 ZAP70_HUMAN (1-619): 0: 641: 100.00		GRB2_HUMAN (37-176): 3.68e-13: 68.6: 32.39
+	Mm
		796503 ZAP70_MOUSE (1-619): 0: 633: 92.90		GRB2_MOUSE (37-176): 3.68e-13: 68.6: 32.39
+	Mm
		975164 EPHA2_MOUSE (20-614): 1.45e-153: 468: 23.76		SLAP1_MOUSE (13-257): 4.05e-58: 188: 40.95
+	Hs
		275178 KSYK_HUMAN (1-600): 0: 554: 53.58		GRAP2_HUMAN (37-176): 3.39e-15: 75.9: 37.14
+	Hs
		796538 KSYK_HUMAN (1-600): 0: 554: 53.58		GRB2_HUMAN (37-176): 3.68e-13: 68.6: 32.39