HitPredict

Interactor 1: ZAP70 (P43404)
Tyrosine-protein kinase ZAP-70 (EC 2.7.10.2) (70 kDa zeta-chain associated protein) (Syk-related tyrosine kinase)
Gene: ZAP70

Interactor 2: PHAG1 (Q3U1F9)
Phosphoprotein associated with glycosphingolipid-enriched microdomains 1 (Csk-binding protein) (Transmembrane phosphoprotein Cbp)
Gene: Pag1

Species: Mus musculus

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.41	1.00	0.646

Property	Details
Experiments	26512138
Identification Methods	affinity chromatography technology
Interaction Type	association, physical association

Property	Details
Interacting Pfam domains	PAG~SH2
Common GO terms	GO:0002250 - adaptive immune response GO:0005886 - plasma membrane GO:0035556 - intracellular signal transduction GO:0045121 - membrane raft
Homologous interactions	16

Homologous interactions

Color coding for hit scores

	1 618 Mm			1 429
+	Hs
		796485 ZAP70_HUMAN (1-618): 0: 615: 93.39		PHAG1_HUMAN (1-429): 0: 705: 78.21
+	Mm
		639443 LYN_MOUSE (77-607): 9.33e-161: 472: 26.11		PHAG1_MOUSE (1-429): 0: 785: 100.00
+	Hs
		796661 KSYK_HUMAN (1-598): 0: 543: 54.05		PHAG1_HUMAN (1-429): 0: 705: 78.21
+	Rn
		70092 B2B9B0_RAT (56-610): 2.23e-149: 458: 24.56		PHAG1_RAT (1-429): 0: 764: 89.51
+	Mm
		411925 LCK_MOUSE (58-607): 6.25e-145: 431: 25.40		PHAG1_MOUSE (1-429): 0: 785: 100.00
+	Mm
		976830 ITK_MOUSE (78-595): 1.17e-142: 429: 25.18		PHAG1_MOUSE (1-429): 0: 785: 100.00
+	Mm
		763390 FYN_MOUSE (62-609): 8.61e-141: 421: 25.00		PHAG1_MOUSE (1-429): 0: 785: 100.00
+	Mm
		782848 CSK_MOUSE (128-595): 4.95e-141: 419: 29.75		PHAG1_MOUSE (1-429): 0: 785: 100.00
+	Rn
		693647 CSK_RAT (128-598): 2.42e-141: 420: 29.56		PHAG1_RAT (1-429): 0: 764: 89.51
+	Hs
		337571 ABL1_HUMAN (109-596): 7.56e-150: 463: 28.09		PHAG1_HUMAN (1-429): 0: 705: 78.21
+	Hs
		434038 LYN_HUMAN (75-607): 1.41e-154: 456: 25.83		PHAG1_HUMAN (1-429): 0: 705: 78.21
+	Hs
		789135 FRK_HUMAN (80-601): 9.02e-151: 446: 25.98		PHAG1_HUMAN (1-429): 0: 705: 78.21
+	Hs
		411873 LCK_HUMAN (58-607): 3.03e-144: 429: 25.09		PHAG1_HUMAN (1-429): 0: 705: 78.21
+	Hs
		412375 FYN_HUMAN (62-609): 7.32e-141: 422: 25.00		PHAG1_HUMAN (1-429): 0: 705: 78.21
+	Hs
		782829 CSK_HUMAN (128-595): 6.35e-141: 418: 29.75		PHAG1_HUMAN (1-429): 0: 705: 78.21
+	Hs
		523175 SRC_HUMAN (51-609): 4.53e-138: 414: 23.49		PHAG1_HUMAN (1-429): 0: 705: 78.21