HitPredict

Interactor 1: ZAP70 (P43404)
Tyrosine-protein kinase ZAP-70 (EC 2.7.10.2) (70 kDa zeta-chain associated protein) (Syk-related tyrosine kinase)
Gene: ZAP70

Interactor 2: RHOH (Q9D3G9)
Rho-related GTP-binding protein RhoH
Gene: RHOH

Species: Mus musculus

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.33	0.60	0.445

Property	Details
Experiments	24584089
Identification Methods	affinity chromatography technology
Interaction Type	association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0001772 - immunological synapse GO:0005737 - cytoplasm GO:0005886 - plasma membrane GO:0030217 - T cell differentiation GO:0045582 - positive regulation of T cell differentiation
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 618 Mm			1 191
+	Hs
		796474 ZAP70_HUMAN (1-618): 0: 615: 93.39		RHOH_HUMAN (1-191): 3.93e-94: 273: 96.86
+	Hs
		796539 KSYK_HUMAN (1-598): 0: 543: 54.05		RAC1_HUMAN (2-191): 6.42e-75: 224: 38.58
+	Hs
		1072503 EPHA7_HUMAN (55-612): 7.2e-157: 477: 23.16		RHOH_HUMAN (1-191): 3.93e-94: 273: 96.86
+	Hs
		436317 EPHA7_HUMAN (55-612): 7.2e-157: 477: 23.16		RHOC_HUMAN (6-180): 1.96e-84: 249: 40.66
+	Hs
		915694 EPHA7_HUMAN (55-612): 7.2e-157: 477: 23.16		RHOB_HUMAN (6-191): 1.53e-84: 249: 40.42
+	Hs
		436223 EPHA5_HUMAN (66-614): 1.32e-149: 460: 23.13		RHOC_HUMAN (6-180): 1.96e-84: 249: 40.66
+	Hs
		925297 EPHA7_HUMAN (55-612): 7.2e-157: 477: 23.16		RAC1_HUMAN (2-191): 6.42e-75: 224: 38.58
+	Hs
		564541 EPHA7_HUMAN (55-612): 7.2e-157: 477: 23.16		RHOQ_HUMAN (5-190): 2.01e-72: 219: 38.46
+	Hs
		545394 EPHA7_HUMAN (55-612): 7.2e-157: 477: 23.16		RAC2_HUMAN (2-191): 3.16e-72: 218: 37.56
+	Hs
		951011 EPHA7_HUMAN (55-612): 7.2e-157: 477: 23.16		RHOG_HUMAN (2-191): 1.66e-72: 218: 37.56
+	Hs
		892388 EPHA7_HUMAN (55-612): 7.2e-157: 477: 23.16		RAC3_HUMAN (2-171): 5.46e-72: 217: 42.37
+	Hs
		900497 EPHA7_HUMAN (55-612): 7.2e-157: 477: 23.16		RHOA_HUMAN (6-191): 4.22e-71: 215: 37.31
+	Hs
		665387 EPHA3_HUMAN (54-614): 1.02e-155: 474: 23.89		RAC3_HUMAN (2-171): 5.46e-72: 217: 42.37
+	Hs
		789055 ABL2_HUMAN (103-616): 1.55e-149: 463: 27.66		RAC1_HUMAN (2-191): 6.42e-75: 224: 38.58
+	Hs
		564442 ABL2_HUMAN (103-616): 1.55e-149: 463: 27.66		RHOQ_HUMAN (5-190): 2.01e-72: 219: 38.46
+	Hs
		545245 ABL2_HUMAN (103-616): 1.55e-149: 463: 27.66		RAC2_HUMAN (2-191): 3.16e-72: 218: 37.56
+	Hs
		789050 ABL2_HUMAN (103-616): 1.55e-149: 463: 27.66		RAC3_HUMAN (2-171): 5.46e-72: 217: 42.37
+	Hs
		545285 EPHA5_HUMAN (66-614): 1.32e-149: 460: 23.13		RAC2_HUMAN (2-191): 3.16e-72: 218: 37.56
+	Hs
		789051 ABL2_HUMAN (103-616): 1.55e-149: 463: 27.66		CDC42_HUMAN (2-191): 6.53e-71: 214: 40.10
+	Hs
		872418 EPHA5_HUMAN (66-614): 1.32e-149: 460: 23.13		RAC3_HUMAN (2-171): 5.46e-72: 217: 42.37