Interactor 1: KSYK (P43405)
Tyrosine-protein kinase SYK (EC 2.7.10.2) (Spleen tyrosine kinase) (p72-Syk)
Gene: SYK

Interactor 2: KSYK (P43405)
Tyrosine-protein kinase SYK (EC 2.7.10.2) (Spleen tyrosine kinase) (p72-Syk)
Gene: SYK

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score Annotation score Interaction score
0.91 1.00 0.958

The method score is based on:

Property Details
Experiments 9698567, 18070606, 16291755, 10617633, 10438543, 25605870, 24525236
Identification Methods x-ray crystallography, enzymatic study, in-gel kinase assay, protein kinase assay
Interaction Type association, direct interaction, phosphorylation reaction

The annotation score is based on:

Property Details
Interacting Pfam domains PK_Tyr_Ser-Thr~PK_Tyr_Ser-Thr, PK_Tyr_Ser-Thr~SH2, SH2~SH2
Common GO terms GO:0001525 - angiogenesis
GO:0001775 - cell activation
GO:0001784 - phosphotyrosine residue binding
GO:0001945 - lymph vessel development
GO:0002092 - positive regulation of receptor internalization
and 96 others

more...

Homologous interactions 20

Homologous interactions (Top 20)

Color coding for hit scores

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Service provided by Combinatics, Japan

Last updated: 15 Jul 2024