HitPredict

Interactor 1: KSYK (P43405)
Tyrosine-protein kinase SYK (EC 2.7.10.2) (Spleen tyrosine kinase) (p72-Syk)
Gene: SYK

Interactor 2: RACK1 (P63244)
Small ribosomal subunit protein RACK1 (Cell proliferation-inducing gene 21 protein) (Guanine nucleotide-binding protein subunit beta-2-like 1) (Guanine nucleotide-binding protein subunit beta-like protein 12.3) (Human lung cancer oncogene 7 protein) (HLC-7) (Receptor for activated C kinase) (Receptor of activated protein C kinase 1) [Cleaved into: Small ribosomal subunit protein RACK1, N-terminally processed (Guanine nucleotide-binding protein subunit beta-2-like 1, N-terminally processed) (Receptor of activated protein C kinase 1, N-terminally processed)]
Gene: RACK1

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.47	0.60	0.536

Property	Details
Experiments	32707033
Identification Methods	affinity chromatography technology, pull down
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005102 - signaling receptor binding GO:0005634 - nucleus GO:0005737 - cytoplasm GO:0005829 - cytosol GO:0031334 - positive regulation of protein-containing complex assembly and 1 others more... GO:0042169 - SH2 domain binding
Homologous interactions	11

Homologous interactions

Color coding for hit scores

	1 635 Hs			1 317
+	Gg
		94456 KSYK_CHICK (3-634): 0: 560: 76.27		RACK1_CHICK (1-317): 2.18e-109: 322: 100.00
+	Hs
		522889 SRC_HUMAN (4-371): 2.15e-70: 239: 15.46		RACK1_HUMAN (1-317): 2.18e-109: 322: 100.00
+	Hs
		412124 FYN_HUMAN (4-201): 3.14e-69: 236: 22.03		RACK1_HUMAN (1-317): 2.18e-109: 322: 100.00
+	Hs
		338260 EGFR_HUMAN (375-619): 8.73e-57: 209: 43.15		RACK1_HUMAN (1-317): 2.18e-109: 322: 100.00
+	Hs
		383733 ERBB2_HUMAN (375-619): 1.47e-52: 197: 42.34		RACK1_HUMAN (1-317): 2.18e-109: 322: 100.00
+	Hs
		616785 JAK1_HUMAN (312-632): 4.51e-39: 156: 20.81		RACK1_HUMAN (1-317): 2.18e-109: 322: 100.00
+	Hs
		383677 ERBB2_HUMAN (375-619): 1.47e-52: 197: 42.34		LIS1_HUMAN (144-316): 6.1e-46: 162: 23.43
+	Hs
		412300 FYN_HUMAN (4-201): 3.14e-69: 236: 22.03		SNR40_HUMAN (226-317): 2.08e-15: 77.7: 22.34
+	Hs
		383918 ERBB2_HUMAN (375-619): 1.47e-52: 197: 42.34		FBXW7_HUMAN (3-128): 4.32e-21: 95.4: 24.63
+	Hs
		383588 ERBB2_HUMAN (375-619): 1.47e-52: 197: 42.34		GBB3_HUMAN (15-260): 4.33e-11: 64.7: 27.38
+	Hs
		616847 JAK1_HUMAN (312-632): 4.51e-39: 156: 20.81		FBXW7_HUMAN (3-128): 4.32e-21: 95.4: 24.63