HitPredict

Interactor 1: KSYK (P43405)
Tyrosine-protein kinase SYK (EC 2.7.10.2) (Spleen tyrosine kinase) (p72-Syk)
Gene: SYK

Interactor 2: LCP2 (Q13094)
Lymphocyte cytosolic protein 2 (SH2 domain-containing leukocyte protein of 76 kDa) (SLP-76 tyrosine phosphoprotein) (SLP76)
Gene: LCP2

Species: Homo sapiens

Source: innatedb

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.58	1.00	0.768

Property	Details
Experiments	22267732, 15388330
Identification Methods	affinity chromatography technology, anti tag coimmunoprecipitation
Interaction Type	physical association, phosphorylation reaction

Property	Details
Interacting Pfam domains	PK_Tyr_Ser-Thr~SH2, SH2~SH2
Common GO terms	GO:0005829 - cytosol GO:0007169 - cell surface receptor protein tyrosine kinase signaling pathway GO:0035556 - intracellular signal transduction
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 635 Hs			1 533
+	Hs
		796468 ZAP70_HUMAN (6-635): 0: 535: 53.57		LCP2_HUMAN (1-533): 1.59e-78: 258: 100.00
+	Hs
		796616 KSYK_HUMAN (1-635): 0: 589: 100.00		BLNK_HUMAN (75-520): 4.29e-35: 139: 24.28
+	Gg
		94506 KSYK_CHICK (3-634): 0: 560: 76.27		BLNK_CHICK (52-520): 2.03e-31: 129: 21.42
+	Hs
		554283 ZAP70_HUMAN (6-635): 0: 535: 53.57		MUC1_HUMAN (87-469): 7.93e-15: 79.7: 9.92
+	Hs
		996556 ITK_HUMAN (136-626): 3.44e-108: 341: 27.60		LCP2_HUMAN (1-533): 1.59e-78: 258: 100.00
+	Mm
		976831 ITK_MOUSE (136-626): 1.92e-106: 336: 26.98		LCP2_MOUSE (1-531): 8.21e-72: 240: 80.98
+	Hs
		411700 LCK_HUMAN (5-201): 3.03e-71: 240: 23.29		LCP2_HUMAN (1-533): 1.59e-78: 258: 100.00
+	Hs
		522951 SRC_HUMAN (4-371): 2.15e-70: 239: 15.46		LCP2_HUMAN (1-533): 1.59e-78: 258: 100.00
+	Hs
		412165 FYN_HUMAN (4-201): 3.14e-69: 236: 22.03		LCP2_HUMAN (1-533): 1.59e-78: 258: 100.00
+	Hs
		508060 FGFR1_HUMAN (179-635): 7.43e-116: 366: 26.24		TENS2_HUMAN (79-512): 3.43e-30: 127: 17.32
+	Mm
		976834 ITK_MOUSE (136-626): 1.92e-106: 336: 26.98		BLNK_MOUSE (78-520): 1.72e-37: 145: 23.27
+	Mm
		763395 FYN_MOUSE (4-201): 6.63e-69: 235: 22.03		LCP2_MOUSE (1-531): 8.21e-72: 240: 80.98
+	Hs
		203204 FGFR1_HUMAN (179-635): 7.43e-116: 366: 26.24		SYNJ1_HUMAN (10-466): 1.18e-22: 104: 11.71
+	Hs
		872663 EPHA4_HUMAN (329-626): 1.47e-105: 343: 34.54		TENS3_HUMAN (83-512): 1.87e-28: 122: 12.50
+	Mm
		763411 FYN_MOUSE (4-201): 6.63e-69: 235: 22.03		CLNK_MOUSE (150-528): 6.78e-37: 143: 28.57
+	Hs
		523025 SRC_HUMAN (4-371): 2.15e-70: 239: 15.46		TENS3_HUMAN (83-512): 1.87e-28: 122: 12.50
+	Hs
		203198 LCK_HUMAN (5-201): 3.03e-71: 240: 23.29		SYNJ1_HUMAN (10-466): 1.18e-22: 104: 11.71
+	Hs
		411582 LCK_HUMAN (5-201): 3.03e-71: 240: 23.29		MUC1_HUMAN (87-469): 7.93e-15: 79.7: 9.92
+	Hs
		522749 SRC_HUMAN (4-371): 2.15e-70: 239: 15.46		MUC1_HUMAN (87-469): 7.93e-15: 79.7: 9.92
+	Hs
		412433 FYN_HUMAN (4-201): 3.14e-69: 236: 22.03		MYO16_HUMAN (111-438): 6.65e-11: 67.4: 12.90