HitPredict

Interactor 1: KSYK (P43405)
Tyrosine-protein kinase SYK (EC 2.7.10.2) (Spleen tyrosine kinase) (p72-Syk)
Gene: SYK

Interactor 2: MEG10 (Q96KG7)
Multiple epidermal growth factor-like domains protein 10 (Multiple EGF-like domains protein 10)
Gene: MEGF10

Species: Homo sapiens

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.38	0.60	0.479

Property	Details
Experiments	22993420
Identification Methods	affinity chromatography technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005886 - plasma membrane
Homologous interactions	18

Homologous interactions

Color coding for hit scores

	1 635 Hs			1 1140
+	Hs
		412309 FYN_HUMAN (4-201): 3.14e-69: 236: 22.03		MEG10_HUMAN (1-1127): 5.88e-179: 557: 100.00
+	Hs
		796590 KSYK_HUMAN (1-635): 0: 589: 100.00		PEAR1_HUMAN (5-308): 4.28e-32: 137: 31.37
+	Hs
		796476 ZAP70_HUMAN (6-635): 0: 535: 53.57		PEAR1_HUMAN (5-308): 4.28e-32: 137: 31.37
+	Hs
		872428 EPHA5_HUMAN (171-632): 5.04e-115: 370: 25.42		NOTC2_HUMAN (3-589): 3.72e-32: 138: 17.92
+	Hs
		980386 NTRK2_HUMAN (158-631): 7.36e-116: 366: 24.27		NOTC2_HUMAN (3-589): 3.72e-32: 138: 17.92
+	Hs
		254229 EGFR_HUMAN (375-619): 8.73e-57: 209: 43.15		MEGF6_HUMAN (79-991): 3.19e-78: 284: 22.12
+	Hs
		872634 EPHA4_HUMAN (329-626): 1.47e-105: 343: 34.54		NOTC2_HUMAN (3-589): 3.72e-32: 138: 17.92
+	Hs
		337952 EGFR_HUMAN (375-619): 8.73e-57: 209: 43.15		TENA_HUMAN (486-1012): 1.26e-46: 185: 15.63
+	Hs
		411684 LCK_HUMAN (5-201): 3.03e-71: 240: 23.29		NOTC2_HUMAN (3-589): 3.72e-32: 138: 17.92
+	Hs
		433384 YES_HUMAN (4-203): 1.25e-68: 234: 20.80		PEAR1_HUMAN (5-308): 4.28e-32: 137: 31.37
+	Hs
		411635 LCK_HUMAN (5-201): 3.03e-71: 240: 23.29		NOTC1_HUMAN (454-991): 2.1e-26: 120: 16.76
+	Hs
		337591 ABL1_HUMAN (4-385): 1.81e-58: 214: 17.07		NOTC3_HUMAN (4-573): 1.83e-33: 143: 19.22
+	Hs
		338310 EGFR_HUMAN (375-619): 8.73e-57: 209: 43.15		NOTC2_HUMAN (3-589): 3.72e-32: 138: 17.92
+	Hs
		337391 ABL1_HUMAN (4-385): 1.81e-58: 214: 17.07		NOTC1_HUMAN (454-991): 2.1e-26: 120: 16.76
+	Hs
		412305 FYN_HUMAN (4-201): 3.14e-69: 236: 22.03		SREC2_HUMAN (729-831): 1.11e-09: 64.7: 35.92
+	Hs
		338533 EGFR_HUMAN (375-619): 8.73e-57: 209: 43.15		EYS_HUMAN (399-983): 2.45e-11: 70.8: 12.66
+	Hs
		337530 ABL1_HUMAN (4-385): 1.81e-58: 214: 17.07		SREC2_HUMAN (729-831): 1.11e-09: 64.7: 35.92
+	Dm
		1096402 SHARK_DROME (11-166): 6.21e-22: 103: 20.00		DRPR_DROME (566-989): 1.18e-35: 149: 26.03