HitPredict

Interactor 1: KSYK (P43405)
Tyrosine-protein kinase SYK (EC 2.7.10.2) (Spleen tyrosine kinase) (p72-Syk)
Gene: SYK

Interactor 2: FCRL3 (Q96P31)
Fc receptor-like protein 3 (FcR-like protein 3) (FcRL3) (Fc receptor homolog 3) (FcRH3) (IFGP family protein 3) (hIFGP3) (Immune receptor translocation-associated protein 3) (MAIA) (SH2 domain-containing phosphatase anchor protein 2) (CD antigen CD307c)
Gene: FCRL3

Species: Homo sapiens

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.41	0.60	0.501

Property	Details
Experiments	12051764
Identification Methods	pull down
Interaction Type	direct interaction

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0019902 - phosphatase binding GO:0043410 - positive regulation of MAPK cascade
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 635 Hs			1 734
+	Hs
		796482 ZAP70_HUMAN (6-635): 0: 535: 53.57		FCRL3_HUMAN (11-734): 1.85e-144: 442: 100.00
+	Hs
		590606 KSYK_HUMAN (1-635): 0: 589: 100.00		CD22_HUMAN (50-655): 2.89e-55: 205: 14.31
+	Hs
		519328 KSYK_HUMAN (1-635): 0: 589: 100.00		FCGR1_HUMAN (84-378): 2.13e-22: 101: 16.72
+	Hs
		519406 KSYK_HUMAN (1-635): 0: 589: 100.00		FCERA_HUMAN (2-185): 3.12e-23: 101: 35.08
+	Mm
		722897 KSYK_MOUSE (1-635): 0: 567: 92.13		CD22_MOUSE (315-734): 7.77e-25: 112: 11.91
+	Hs
		519372 KSYK_HUMAN (1-635): 0: 589: 100.00		FCG2A_HUMAN (16-186): 3.57e-16: 82: 30.34
+	Hs
		442909 KSYK_HUMAN (1-635): 0: 589: 100.00		FCG3A_HUMAN (21-138): 6.41e-15: 77: 35.48
+	Hs
		297881 FYN_HUMAN (4-201): 3.14e-69: 236: 22.03		NFASC_HUMAN (2-716): 1.87e-92: 316: 14.73
+	Hs
		507878 FGFR1_HUMAN (179-635): 7.43e-116: 366: 26.24		L1CAM_HUMAN (8-555): 3.11e-23: 107: 11.91
+	Hs
		508055 FGFR1_HUMAN (179-635): 7.43e-116: 366: 26.24		OBSCN_HUMAN (61-568): 2.44e-10: 66.5: 14.71
+	Hs
		507951 FGFR1_HUMAN (179-635): 7.43e-116: 366: 26.24		PGBM_HUMAN (284-405): 5.26e-10: 65.5: 19.20
+	Dr
		60117 A4QN31_DANRE (187-631): 4.83e-114: 359: 26.28		Q8UVD6_DANRE (29-330): 2.99e-12: 72.3: 15.32
+	Hs
		411584 LCK_HUMAN (5-201): 3.03e-71: 240: 23.29		PECA1_HUMAN (16-371): 2.73e-26: 117: 17.69
+	Hs
		522751 SRC_HUMAN (4-371): 2.15e-70: 239: 15.46		PECA1_HUMAN (16-371): 2.73e-26: 117: 17.69
+	Hs
		411985 FYN_HUMAN (4-201): 3.14e-69: 236: 22.03		PECA1_HUMAN (16-371): 2.73e-26: 117: 17.69
+	Hs
		519400 SRC_HUMAN (4-371): 2.15e-70: 239: 15.46		FCERA_HUMAN (2-185): 3.12e-23: 101: 35.08
+	Hs
		522812 SRC_HUMAN (4-371): 2.15e-70: 239: 15.46		FCG2C_HUMAN (1-202): 2.49e-19: 91.7: 30.62
+	Hs
		522811 SRC_HUMAN (4-371): 2.15e-70: 239: 15.46		FCG2B_HUMAN (1-202): 2.42e-19: 91.3: 30.62
+	Hs
		411560 LCK_HUMAN (5-201): 3.03e-71: 240: 23.29		FCG3A_HUMAN (21-138): 6.41e-15: 77: 35.48
+	Hs
		523003 SRC_HUMAN (4-371): 2.15e-70: 239: 15.46		MYLK_HUMAN (472-563): 5.32e-12: 71.6: 17.53