HitPredict

Interactor 1: KSYK (P43405)
Tyrosine-protein kinase SYK (EC 2.7.10.2) (Spleen tyrosine kinase) (p72-Syk)
Gene: SYK

Interactor 2: UBP25 (Q9UHP3)
Ubiquitin carboxyl-terminal hydrolase 25 (EC 3.4.19.12) (Deubiquitinating enzyme 25) (USP on chromosome 21) (Ubiquitin thioesterase 25) (Ubiquitin-specific-processing protease 25)
Gene: USP25

Species: Homo sapiens

Source: mint

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.91	0.60	0.741

Property	Details
Experiments	21516116, 32296183, 19909739, 25416956, 32707033, unassigned1304
Identification Methods	two hybrid, affinity chromatography technology, validated two hybrid, two hybrid prey pooling approach, two hybrid array, pull down
Interaction Type	direct interaction, physical association, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005634 - nucleus GO:0005737 - cytoplasm GO:0005829 - cytosol
Homologous interactions	16

Homologous interactions

Color coding for hit scores

	1 635 Hs			1 1055
+	Hs
		846538 BLK_HUMAN (162-267): 2.8e-29: 123: 32.43		UBP25_HUMAN (1-1055): 0: 1021: 100.00
+	Hs
		271050 ZAP70_HUMAN (6-635): 0: 535: 53.57		UBP2_HUMAN (514-660): 9.45e-16: 83.8: 17.69
+	Hs
		259268 ZAP70_HUMAN (6-635): 0: 535: 53.57		UBP12_HUMAN (465-658): 3.89e-10: 65: 16.58
+	Hs
		338601 EGFR_HUMAN (375-619): 8.73e-57: 209: 43.15		UBP34_HUMAN (132-425): 1.83e-73: 269: 22.11
+	Hs
		338802 EGFR_HUMAN (375-619): 8.73e-57: 209: 43.15		USP9X_HUMAN (142-459): 2.23e-67: 250: 20.22
+	Hs
		383914 ERBB2_HUMAN (375-619): 1.47e-52: 197: 42.34		USP9X_HUMAN (142-459): 2.23e-67: 250: 20.22
+	Hs
		523210 SRC_HUMAN (4-371): 2.15e-70: 239: 15.46		UBP22_HUMAN (477-661): 1.12e-19: 96.2: 17.30
+	Hs
		411812 LCK_HUMAN (5-201): 3.03e-71: 240: 23.29		UBP7_HUMAN (547-758): 1.65e-17: 90.2: 21.78
+	Hs
		523098 SRC_HUMAN (4-371): 2.15e-70: 239: 15.46		UBP7_HUMAN (547-758): 1.65e-17: 90.2: 21.78
+	Hs
		412293 FYN_HUMAN (4-201): 3.14e-69: 236: 22.03		UBP7_HUMAN (547-758): 1.65e-17: 90.2: 21.78
+	Hs
		337522 ABL1_HUMAN (4-385): 1.81e-58: 214: 17.07		UBP7_HUMAN (547-758): 1.65e-17: 90.2: 21.78
+	Hs
		271010 EGFR_HUMAN (375-619): 8.73e-57: 209: 43.15		UBP2_HUMAN (514-660): 9.45e-16: 83.8: 17.69
+	Hs
		271016 ERBB2_HUMAN (375-619): 1.47e-52: 197: 42.34		UBP2_HUMAN (514-660): 9.45e-16: 83.8: 17.69
+	Hs
		64203 BLK_HUMAN (162-267): 2.8e-29: 123: 32.43		UBP27_HUMAN (477-674): 2.11e-20: 97.3: 16.16
+	Hs
		846546 BLK_HUMAN (162-267): 2.8e-29: 123: 32.43		UBP22_HUMAN (477-661): 1.12e-19: 96.2: 17.30
+	Hs
		850767 BMX_HUMAN (15-193): 8.37e-12: 70.3: 22.82		UBP24_HUMAN (158-405): 3.95e-35: 148: 21.40