HitPredict

Interactor 1: RPN11 (P43588)
Ubiquitin carboxyl-terminal hydrolase RPN11 (EC 3.4.19.12) (26S proteasome regulatory subunit RPN11) (Protein MPR1)
Gene: RPN11

Interactor 2: RPN8 (Q08723)
26S proteasome regulatory subunit RPN8
Gene: RPN8

Species: Saccharomyces cerevisiae S288C

Source: mint

Category: Small-scale

Confidence: High

Method score Annotation score Interaction score
0.98 1.00 0.994

The method score is based on:

Property Details
Experiments 10688190, 24463465, 11595789, 11742986, 15102831, 26182356, 20941496, 24516147, 16284124, 16338358, 22215586, 24038880, 25389291, 26744777, 16554755, 28106073, 28844860, 26929360, 29624167, 28137839 and 16 others

more...
Identification Methods two hybrid, molecular sieving, x-ray crystallography, affinity chromatography technology, pull down, biochemical, protein complementation assay, tandem affinity purification, two hybrid array, dihydrofolate reductase reconstruction
Interaction Type direct interaction, physical association, association

The annotation score is based on:

Property Details
Interacting Pfam domains JAB~JAB, JAB~MitMem_reg
Common GO terms GO:0000502 - proteasome complex
GO:0008237 - metallopeptidase activity
GO:0008541 - proteasome regulatory particle, lid subcomplex
GO:0034515 - proteasome storage granule
GO:0043161 - proteasome-mediated ubiquitin-dependent protein catabolic process
Homologous interactions 20

Homologous interactions (Top 20)

Color coding for hit scores

1 306
Sc

1 338
+ Dm
+ Hs
+ Sp
+ Ce
+ Dm
+ Hs
+ Hs
+ Mm
+ At
+ At
+ At
+ At
+ At
+ Hs
+ Zm
+ Ce
+ An
+ Hs
+ Zm
+ At

Service provided by Combinatics, Japan

Last updated: 15 Jul 2024