HitPredict

Interactor 1: RPN11 (P43588)
Ubiquitin carboxyl-terminal hydrolase RPN11 (EC 3.4.19.12) (26S proteasome regulatory subunit RPN11) (Protein MPR1)
Gene: RPN11

Interactor 2: RPN5 (Q12250)
26S proteasome regulatory subunit RPN5 (Proteasome non-ATPase subunit 5)
Gene: RPN5

Species: Saccharomyces cerevisiae S288C

Source: mint

Category: Small-scale

Confidence: High

Method score Annotation score Interaction score
0.98 1.00 0.993

The method score is based on:

Property Details
Experiments 11742986, 11805826, 16284124, 16338358, 22215586, 24038880, 26744777, 26450923, 26182356, 28106073, 26929360, 29624167, 19446323, 18314965, 34161281, 27405762, 31601863, 15917626, 21321079, 21627799 and 14 others

more...
Identification Methods two hybrid, tandem affinity purification, affinity chromatography technology, biochemical, pull down, protein complementation assay, anti tag coimmunoprecipitation, dihydrofolate reductase reconstruction
Interaction Type physical association, association, direct interaction

The annotation score is based on:

Property Details
Interacting Pfam domains JAB~PCI, JAB~RPN5_C
Common GO terms GO:0000502 - proteasome complex
GO:0008541 - proteasome regulatory particle, lid subcomplex
GO:0034515 - proteasome storage granule
GO:0043161 - proteasome-mediated ubiquitin-dependent protein catabolic process
Homologous interactions 20

Homologous interactions (Top 20)

Color coding for hit scores

1 306
Sc

1 445
+ Hs
+ Dm
+ Dm
+ Hs
+ Sp
+ At
+ At
+ Dm
+ Mm
+ Hs
+ Dm
+ An
+ Sc
+ Mm
+ Hs
+ Ce
+ At
+ At
+ Ce
+ An

Service provided by Combinatics, Japan

Last updated: 15 Jul 2024